Coregulator-dependent Facilitation of Chromatin Occupancy by GATA-1

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2004 Jan 13

PMID 14715908

Citations 82

Authors

Saumen Pal

Alan B Cantor

Kirby D Johnson

Tyler B Moran

Meghan E Boyer

Stuart H Orkin

Emery H Bresnick

Affiliations

Soon will be listed here.

Abstract

Coregulator recruitment by DNA-bound factors results in chromatin modification and protein-protein interactions, which regulate transcription. However, the mechanism by which the Friend of GATA (FOG) coregulator mediates GATA factor-dependent transcription is unknown. We showed previously that GATA-1 replaces GATA-2 at an upstream region of the GATA-2 locus, and that this GATA switch represses GATA-2. Genetic complementation analysis in FOG-1-null hematopoietic precursors revealed that FOG-1 is not required for establishment or maintenance of the active GATA-2 domain, but is critical for the GATA switch. Analysis of GATA factor binding to additional loci also revealed FOG-1-dependent GATA switches. Thus, FOG-1 facilitates chromatin occupancy by GATA-1 at sites bound by GATA-2. We propose that FOG-1 is a prototype of a new class of coregulators termed chromatin occupancy facilitators, which confer coregulation in certain contexts via enhancing trans-acting factor binding to chromatin in vivo.

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