The Evi1, MicroRNA-143, K-Ras Axis in Colon Cancer

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2011 Feb 1

PMID 21276449

Citations 15

Authors

Jin-Song Gao

Yingjie Zhang

Xiaoli Tang

Lynne D Tucker

Patrick M Tarwater

Peter J Quesenberry

Isidore Rigoutsos

Bharat Ramratnam

Affiliations

Soon will be listed here.

Abstract

MicroRNA profiling of diseased/non-diseased tissue has identified expression signatures associated with a wide range of pathogenic conditions including malignancy. For example, colon cancer is associated with the under expression of miRNA-143 yet the molecular etiology of under expression is unknown. The K-Ras oncogene is a target of miRNA-143. Here, we show that the ecotropic viral integration site 1 oncoprotein (Evi1) is a transcriptional suppressor of the miRNA-143 gene. We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer.

Citing Articles

Visualization of microRNA-21 Dynamics in Neuroblastoma Using Magnetic Resonance Imaging Based on a microRNA-21-Responsive Reporter Gene.

Bao G, Sun J, Zheng H, Hou J, Huang J, Wei J Front Oncol. 2021; 11:747305.

PMID: 34804934 PMC: 8602822. DOI: 10.3389/fonc.2021.747305.

The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer.

Roncarati R, Lupini L, Shankaraiah R, Negrini M Front Oncol. 2019; 9:988.

PMID: 31612113 PMC: 6777413. DOI: 10.3389/fonc.2019.00988.

EVI1 promotes epithelial-to-mesenchymal transition, cancer stem cell features and chemo-/radioresistance in nasopharyngeal carcinoma.

Lu Y, Liang Y, Zheng X, Deng X, Huang W, Zhang G J Exp Clin Cancer Res. 2019; 38(1):82.

PMID: 30770775 PMC: 6377731. DOI: 10.1186/s13046-019-1077-3.

Ecotropic viral integration site 1 regulates the progression of acute myeloid leukemia via MS4A3-mediated TGFβ/EMT signaling pathway.

Jiang M, Zou X, Huang W Oncol Lett. 2018; 16(2):2701-2708.

PMID: 30013666 PMC: 6036571. DOI: 10.3892/ol.2018.8890.

GIMDA: Graphlet interaction-based MiRNA-disease association prediction.

Chen X, Guan N, Li J, Yan G J Cell Mol Med. 2017; 22(3):1548-1561.

PMID: 29272076 PMC: 5824414. DOI: 10.1111/jcmm.13429.

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