GI GEMs: Genetically Engineered Mouse Models of Gastrointestinal Disease

Overview

Journal Gastroenterology

Specialty Gastroenterology

Date 2010 Dec 21

PMID 21167162

Citations 4

Authors

Thomas Doetschman

Affiliations

Soon will be listed here.

Citing Articles

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Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population.

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Mammalian models of chemically induced primary malignancies exploitable for imaging-based preclinical theragnostic research.

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Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans.

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References

Donehower L, Harvey M, Slagle B, McArthur M, Montgomery Jr C, Butel J . Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992; 356(6366):215-21. DOI: 10.1038/356215a0. View

Orban P, Chui D, Marth J . Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci U S A. 1992; 89(15):6861-5. PMC: 49604. DOI: 10.1073/pnas.89.15.6861. View

Simin K, Hill R, Song Y, Zhang Q, Bash R, Cardiff R . Deciphering cancer complexities in genetically engineered mice. Cold Spring Harb Symp Quant Biol. 2006; 70:283-90. DOI: 10.1101/sqb.2005.70.038. View

Datto M, Frederick J, Pan L, Borton A, Zhuang Y, Wang X . Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol. 1999; 19(4):2495-504. PMC: 84042. DOI: 10.1128/MCB.19.4.2495. View

Wagner T, Hoppe P, Jollick J, Scholl D, Hodinka R, Gault J . Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring. Proc Natl Acad Sci U S A. 1981; 78(10):6376-80. PMC: 349042. DOI: 10.1073/pnas.78.10.6376. View

Sodir N, Chen X, Park R, Nickel A, Conti P, Moats R . Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res. 2006; 66(17):8430-8. DOI: 10.1158/0008-5472.CAN-06-1437. View

Fong L, Newberne P . Nitrosobenzylmethylamine, zinc deficiency and oesophageal cancer. IARC Sci Publ (1971). 1978; (19):503-13. View

Grosveld F, Van Assendelft G, Greaves D, Kollias G . Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell. 1987; 51(6):975-85. DOI: 10.1016/0092-8674(87)90584-8. View

Papaioannou V, McBurney M, Gardner R, Evans M . Fate of teratocarcinoma cells injected into early mouse embryos. Nature. 1975; 258(5530):70-73. DOI: 10.1038/258070a0. View

10.

Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones E, Rickman B . Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell. 2008; 14(5):408-19. PMC: 2586894. DOI: 10.1016/j.ccr.2008.10.011. View

11.

Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, Jung A . Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis. Cancer Cell. 2010; 18(2):135-46. DOI: 10.1016/j.ccr.2010.06.013. View

12.

Rudolph U, Finegold M, Rich S, Harriman G, Srinivasan Y, Brabet P . Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet. 1995; 10(2):143-50. DOI: 10.1038/ng0695-143. View

13.

Gu G, Brown J, Melton D . Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev. 2002; 120(1):35-43. DOI: 10.1016/s0925-4773(02)00330-1. View

14.

Mansour S . Gene targeting in murine embryonic stem cells: introduction of specific alterations into the mammalian genome. Genet Anal Tech Appl. 1990; 7(8):219-27. DOI: 10.1016/0735-0651(90)90004-y. View

15.

Falk G . Barrett's esophagus. Gastroenterology. 2002; 122(6):1569-91. DOI: 10.1053/gast.2002.33427. View

16.

Evans M, Kaufman M . Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981; 292(5819):154-6. DOI: 10.1038/292154a0. View

17.

Thomas K, Capecchi M . Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell. 1987; 51(3):503-12. DOI: 10.1016/0092-8674(87)90646-5. View

18.

Opitz O, Harada H, Suliman Y, Rhoades B, Sharpless N, Kent R . A mouse model of human oral-esophageal cancer. J Clin Invest. 2002; 110(6):761-9. PMC: 151126. DOI: 10.1172/JCI15324. View

19.

Lechpammer M, Xu X, Ellis F, Bhattacharaya N, Shapiro G, Loda M . Flavopiridol reduces malignant transformation of the esophageal mucosa in p27 knockout mice. Oncogene. 2005; 24(10):1683-8. DOI: 10.1038/sj.onc.1208375. View

20.

Koller B, SMITHIES O . Altering genes in animals by gene targeting. Annu Rev Immunol. 1992; 10:705-30. DOI: 10.1146/annurev.iy.10.040192.003421. View