Transforming Growth Factor β Superfamily Signaling In Development of Colorectal Cancer

Overview

Journal Gastroenterology

Specialty Gastroenterology

Date 2016 Oct 25

PMID 27773809

Citations 128

Authors

Barbara Jung

Jonas J Staudacher

Daniel Beauchamp

Affiliations

Soon will be listed here.

Abstract

Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.

Citing Articles

Inflammation in cancer: therapeutic opportunities from new insights.

Xie Y, Liu F, Wu Y, Zhu Y, Jiang Y, Wu Q Mol Cancer. 2025; 24(1):51.

PMID: 39994787 PMC: 11849313. DOI: 10.1186/s12943-025-02243-8.

The plasticity of epithelial cells and its potential in the induced differentiation of gastric cancer.

Yan Z, Liu Y, Yuan Y Cell Death Discov. 2024; 10(1):512.

PMID: 39719478 PMC: 11668900. DOI: 10.1038/s41420-024-02275-x.

Clinical and genetic drivers of oligo-metastatic disease in colon cancer.

Ottaiano A, Santorsola M, Sirica R, Di Mauro A, Di Carlo A, Ianniello M Neoplasia. 2024; 60:101111.

PMID: 39709701 PMC: 11846493. DOI: 10.1016/j.neo.2024.101111.

Exploring the Role of the TGF-β Signaling Pathway in Colorectal Precancerous Polyps Biochemical Genetics.

Sadri S, Aghajani A, Soleimani H, Ghorbani Kalkhajeh S, Nazari H, Brouki Milan P Biochem Genet. 2024; .

PMID: 39636332 DOI: 10.1007/s10528-024-10988-y.

SNPs and blood inflammatory marker featured machine learning for predicting the efficacy of fluorouracil-based chemotherapy in colorectal cancer.

Li J, Zhang W, Chen L, Mao X, Wang X, Liu J Sci Rep. 2024; 14(1):27700.

PMID: 39532939 PMC: 11557704. DOI: 10.1038/s41598-024-79036-4.

References

de Caestecker M, Piek E, Roberts A . Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst. 2000; 92(17):1388-402. DOI: 10.1093/jnci/92.17.1388. View

Landskron G, De la Fuente M, Thuwajit P, Thuwajit C, Hermoso M . Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res. 2014; 2014:149185. PMC: 4036716. DOI: 10.1155/2014/149185. View

Pasche B, Kolachana P, Nafa K, Satagopan J, Chen Y, Lo R . TbetaR-I(6A) is a candidate tumor susceptibility allele. Cancer Res. 1999; 59(22):5678-82. View

Hedger M, Winnall W, Phillips D, de Kretser D . The regulation and functions of activin and follistatin in inflammation and immunity. Vitam Horm. 2011; 85:255-97. DOI: 10.1016/B978-0-12-385961-7.00013-5. View

de Miranda N, van Dinther M, van den Akker B, van Wezel T, Ten Dijke P, Morreau H . Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2. Gastroenterology. 2015; 148(7):1427-37.e8. DOI: 10.1053/j.gastro.2015.02.052. View

Thomson J, Machado R, Pauciulo M, Morgan N, Yacoub M, Corris P . Familial and sporadic primary pulmonary hypertension is caused by BMPR2 gene mutations resulting in haploinsufficiency of the bone morphogenetic protein tùype II receptor. J Heart Lung Transplant. 2001; 20(2):149. DOI: 10.1016/s1053-2498(01)00259-5. View

Itatani Y, Kawada K, Fujishita T, Kakizaki F, Hirai H, Matsumoto T . Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis. Gastroenterology. 2013; 145(5):1064-1075.e11. DOI: 10.1053/j.gastro.2013.07.033. View

Beppu H, Mwizerwa O, Beppu Y, Dattwyler M, Lauwers G, Bloch K . Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene. 2007; 27(8):1063-70. DOI: 10.1038/sj.onc.1210720. View

Akhurst R, Hata A . Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov. 2012; 11(10):790-811. PMC: 3520610. DOI: 10.1038/nrd3810. View

10.

Nishita M, Hashimoto M, Ogata S, Laurent M, Ueno N, Shibuya H . Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature. 2000; 403(6771):781-5. DOI: 10.1038/35001602. View

11.

Stange K, Desir J, Kakar N, Mueller T, Budde B, Gordon C . A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia. Orphanet J Rare Dis. 2015; 10:84. PMC: 4482310. DOI: 10.1186/s13023-015-0299-5. View

12.

Piersma B, Bank R, Boersema M . Signaling in Fibrosis: TGF-β, WNT, and YAP/TAZ Converge. Front Med (Lausanne). 2015; 2:59. PMC: 4558529. DOI: 10.3389/fmed.2015.00059. View

13.

Grady W, Rajput A, Myeroff L, Liu D, Kwon K, Willis J . Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res. 1998; 58(14):3101-4. View

14.

Shi Y, Massague J . Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003; 113(6):685-700. DOI: 10.1016/s0092-8674(03)00432-x. View

15.

Howe J, Bair J, Sayed M, Anderson M, Mitros F, Petersen G . Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet. 2001; 28(2):184-7. DOI: 10.1038/88919. View

16.

Chen J, Walton K, Winbanks C, Murphy K, Thomson R, Makanji Y . Elevated expression of activins promotes muscle wasting and cachexia. FASEB J. 2014; 28(4):1711-23. DOI: 10.1096/fj.13-245894. View

17.

Zhou X, Wang J, Lu J, Song Y, Kwak K, Jiao Q . Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell. 2010; 142(4):531-43. DOI: 10.1016/j.cell.2010.07.011. View

18.

Syngal S, Brand R, Church J, Giardiello F, Hampel H, Burt R . ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015; 110(2):223-62. PMC: 4695986. DOI: 10.1038/ajg.2014.435. View

19.

Yi S, Daluiski A, Pederson R, Rosen V, Lyons K . The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development. 2000; 127(3):621-30. DOI: 10.1242/dev.127.3.621. View

20.

Jones K, Mansell A, Patella S, Scott B, Hedger M, de Kretser D . Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Proc Natl Acad Sci U S A. 2007; 104(41):16239-44. PMC: 2042191. DOI: 10.1073/pnas.0705971104. View