Diamino-1,2,4-triazole Derivatives Are Selective Inhibitors of TYK2 and JAK1 over JAK2 and JAK3

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2010 Nov 26

PMID 21106455

Citations 5

Authors

Jeremiah P Malerich

Jennifer S Lam

Barry Hart

Richard M Fine

Boris Klebansky

Mary J Tanga

Annalisa DAndrea

Affiliations

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Abstract

Tyrosine kinase 2 (TYK2) is required for signaling of interleukin-23 (IL-23), which plays a key role in rheumatoid arthritis. Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1-3.

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