Networking Erythropoiesis

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2010 Nov 25

PMID 21098097

Citations 57

Authors

Marc A Kerenyi

Stuart H Orkin

Affiliations

Soon will be listed here.

Abstract

A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene expression profiling, and comprehensive bioinformatic analyses, offer new insights into the intricacies of red cell molecular circuits.

Citing Articles

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The heterogeneity of erythroid cells: insight at the single-cell transcriptome level.

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Composition of thrombi in zebrafish: similarities and distinctions with mammals.

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References

Dore L, Amigo J, Dos Santos C, Zhang Z, Gai X, Tobias J . A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A. 2008; 105(9):3333-8. PMC: 2265118. DOI: 10.1073/pnas.0712312105. View

Yu L, Ji W, Zhang H, Renda M, He Y, Lin S . SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. J Exp Med. 2010; 207(6):1183-95. PMC: 2882842. DOI: 10.1084/jem.20092215. View

Cantor A, Orkin S . Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 2002; 21(21):3368-76. DOI: 10.1038/sj.onc.1205326. View

Patrick D, Zhang C, Tao Y, Yao H, Qi X, Schwartz R . Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev. 2010; 24(15):1614-9. PMC: 2912559. DOI: 10.1101/gad.1942810. View

Wadman I, Osada H, Grutz G, Agulnick A, Westphal H, Forster A . The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 1997; 16(11):3145-57. PMC: 1169933. DOI: 10.1093/emboj/16.11.3145. View

Schuettengruber B, Chourrout D, Vervoort M, LeBlanc B, Cavalli G . Genome regulation by polycomb and trithorax proteins. Cell. 2007; 128(4):735-45. DOI: 10.1016/j.cell.2007.02.009. View

Richmond T, Chohan M, Barber D . Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol. 2005; 15(3):146-55. DOI: 10.1016/j.tcb.2005.01.007. View

Pepke S, Wold B, Mortazavi A . Computation for ChIP-seq and RNA-seq studies. Nat Methods. 2009; 6(11 Suppl):S22-32. PMC: 4121056. DOI: 10.1038/nmeth.1371. View

Evans T, Felsenfeld G . The erythroid-specific transcription factor Eryf1: a new finger protein. Cell. 1989; 58(5):877-85. DOI: 10.1016/0092-8674(89)90940-9. View

10.

Hodge D, Coghill E, Keys J, Maguire T, Hartmann B, McDowall A . A global role for EKLF in definitive and primitive erythropoiesis. Blood. 2005; 107(8):3359-70. PMC: 1895762. DOI: 10.1182/blood-2005-07-2888. View

11.

Fujiwara T, OGeen H, Keles S, Blahnik K, Linnemann A, Kang Y . Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009; 36(4):667-81. PMC: 2784893. DOI: 10.1016/j.molcel.2009.11.001. View

12.

Yu D, Dos Santos C, Zhao G, Jiang J, Amigo J, Khandros E . miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev. 2010; 24(15):1620-33. PMC: 2912560. DOI: 10.1101/gad.1942110. View

13.

Snow J, Kim J, Currie C, Xu J, Orkin S . Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). J Biol Chem. 2010; 285(36):28064-75. PMC: 2934671. DOI: 10.1074/jbc.M109.096909. View

14.

MILLER I, Bieker J . A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol Cell Biol. 1993; 13(5):2776-86. PMC: 359658. DOI: 10.1128/mcb.13.5.2776-2786.1993. View

15.

Saleque S, Kim J, Rooke H, Orkin S . Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007; 27(4):562-72. DOI: 10.1016/j.molcel.2007.06.039. View

16.

Hung H, Lau J, Kim A, Weiss M, Blobel G . CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites. Mol Cell Biol. 1999; 19(5):3496-505. PMC: 84142. DOI: 10.1128/MCB.19.5.3496. View

17.

Boyes J, Byfield P, Nakatani Y, Ogryzko V . Regulation of activity of the transcription factor GATA-1 by acetylation. Nature. 1998; 396(6711):594-8. DOI: 10.1038/25166. View

18.

Kassouf M, Chagraoui H, Vyas P, Porcher C . Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis. Blood. 2008; 112(4):1056-67. DOI: 10.1182/blood-2007-12-128900. View

19.

Weiss M, Yu C, Orkin S . Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Mol Cell Biol. 1997; 17(3):1642-51. PMC: 231889. DOI: 10.1128/MCB.17.3.1642. View

20.

Rodriguez P, Bonte E, Krijgsveld J, Kolodziej K, Guyot B, Heck A . GATA-1 forms distinct activating and repressive complexes in erythroid cells. EMBO J. 2005; 24(13):2354-66. PMC: 1173143. DOI: 10.1038/sj.emboj.7600702. View