Sphingosine-1-phosphate Antibodies As Potential Agents in the Treatment of Cancer and Age-related Macular Degeneration

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2010 Nov 25

PMID 21091645

Citations 44

Authors

Roger A Sabbadini

Affiliations

Soon will be listed here.

Abstract

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.

Citing Articles

Melanophilin inhibit the growth and lymph node metastasis of triple negative breast cancer via the NONO-SPHK1-S1P axis.

Yao X, Yuen T, Qingchuan C, Jianjun Z, Yefu L, Shulan S J Transl Med. 2025; 23(1):284.

PMID: 40050909 PMC: 11887221. DOI: 10.1186/s12967-025-06240-9.

Making a difference.

Sabbadini R Eur J Transl Myol. 2024; 34(3).

PMID: 39105478 PMC: 11487635. DOI: 10.4081/ejtm.2024.12811.

Application of sphingolipid-based nanocarriers in drug delivery: an overview.

Kumar S, Singh A, Pandey P, Khopade A, Sawant K Ther Deliv. 2024; 15(8):619-637.

PMID: 39072358 PMC: 11412150. DOI: 10.1080/20415990.2024.2377066.

Targeting Sphingosine-1-Phosphate Signaling in Breast Cancer.

Nagahashi M, Miyoshi Y Int J Mol Sci. 2024; 25(6).

PMID: 38542328 PMC: 10970081. DOI: 10.3390/ijms25063354.

Intestinal Inflammation and Regeneration-Interdigitating Processes Controlled by Dietary Lipids in Inflammatory Bowel Disease.

Kwon S, Khan M, Kim S Int J Mol Sci. 2024; 25(2).

PMID: 38279309 PMC: 10816399. DOI: 10.3390/ijms25021311.

References

Visentin B, Vekich J, Sibbald B, Cavalli A, Moreno K, Matteo R . Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell. 2006; 9(3):225-38. DOI: 10.1016/j.ccr.2006.02.023. View

Im D . New intercellular lipid mediators and their GPCRs: an update. Prostaglandins Other Lipid Mediat. 2009; 89(3-4):53-6. DOI: 10.1016/j.prostaglandins.2009.01.002. View

Ishibashi T, Inomata H, Sakamoto T, Ryan S . Pericytes of newly formed vessels in experimental subretinal neovascularization. Arch Ophthalmol. 1995; 113(2):227-31. DOI: 10.1001/archopht.1995.01100020111041. View

Ruckhaberle E, Rody A, Engels K, Gaetje R, von Minckwitz G, Schiffmann S . Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res Treat. 2007; 112(1):41-52. DOI: 10.1007/s10549-007-9836-9. View

Lucke S, Levkau B . Endothelial functions of sphingosine-1-phosphate. Cell Physiol Biochem. 2010; 26(1):87-96. DOI: 10.1159/000315109. View

Ho J, Man K, Sun C, Lee T, Poon R, Fan S . Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. Mol Cancer Ther. 2005; 4(9):1430-8. DOI: 10.1158/1535-7163.MCT-05-0021. View

Hobson J, Rosenfeldt H, Barak L, Olivera A, Poulton S, Caron M . Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science. 2001; 291(5509):1800-3. DOI: 10.1126/science.1057559. View

Melendez A, Gosink M, Allen J, Takacs L . Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution. Gene. 2000; 251(1):19-26. DOI: 10.1016/s0378-1119(00)00205-5. View

Caballero S, Swaney J, Moreno K, Afzal A, Kielczewski J, Stoller G . Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization. Exp Eye Res. 2008; 88(3):367-77. PMC: 3756152. DOI: 10.1016/j.exer.2008.07.012. View

10.

Goetzl E, Graeler M, Huang M, Shankar G . Lysophospholipid growth factors and their G protein-coupled receptors in immunity, coronary artery disease, and cancer. ScientificWorldJournal. 2003; 2:324-38. PMC: 6009231. DOI: 10.1100/tsw.2002.124. View

11.

Cuvillier O, Pirianov G, Kleuser B, Vanek P, Coso O, Gutkind S . Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature. 1996; 381(6585):800-3. DOI: 10.1038/381800a0. View

12.

Maceyka M, Milstien S, Spiegel S . Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. Prostaglandins Other Lipid Mediat. 2005; 77(1-4):15-22. DOI: 10.1016/j.prostaglandins.2004.09.010. View

13.

Xia P, Gamble J, Wang L, Pitson S, Moretti P, Wattenberg B . An oncogenic role of sphingosine kinase. Curr Biol. 2000; 10(23):1527-30. DOI: 10.1016/s0960-9822(00)00834-4. View

14.

Swaney J, Moreno K, Gentile A, Sabbadini R, Stoller G . Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. Exp Eye Res. 2008; 87(4):367-75. DOI: 10.1016/j.exer.2008.07.005. View

15.

Shida D, Fang X, Kordula T, Takabe K, Lepine S, Alvarez S . Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. Cancer Res. 2008; 68(16):6569-77. PMC: 2763580. DOI: 10.1158/0008-5472.CAN-08-0411. View

16.

Bektas M, Payne S, Liu H, Goparaju S, Milstien S, Spiegel S . A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. J Cell Biol. 2005; 169(5):801-11. PMC: 2171605. DOI: 10.1083/jcb.200407123. View

17.

Argraves K, Wilkerson B, Argraves W, Fleming P, Obeid L, Drake C . Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis. J Biol Chem. 2004; 279(48):50580-90. DOI: 10.1074/jbc.M404432200. View

18.

Sanchez T, Estrada-Hernandez T, Paik J, Wu M, Venkataraman K, Brinkmann V . Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem. 2003; 278(47):47281-90. DOI: 10.1074/jbc.M306896200. View

19.

Lucas da Silva L, Ribeiro D, Cury P, Cordeiro J, Bueno V . FTY720 treatment in experimentally urethane-induced lung tumors. J Exp Ther Oncol. 2008; 7(1):9-15. View

20.

Tanimoto T, Jin Z, Berk B . Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J Biol Chem. 2002; 277(45):42997-3001. DOI: 10.1074/jbc.M204764200. View