The Relationship Between Early Embryo Development and Tumourigenesis

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2010 Oct 30

PMID 21029369

Citations 99

Authors

Yanlei Ma

Peng Zhang

Feng Wang

Jianjun Yang

Zhe Yang

Huanlong Qin

Affiliations

Soon will be listed here.

Abstract

With the recent substantial progress in developmental biology and cancer biology, the similarities between early embryo development and tumourigenesis, as well as the important interaction between tumours and embryos become better appreciated. In this paper, we review in detail the embryonic origin of tumour, and the similarities between early embryo development and tumourigenesis with respect to cell invasive behaviours, epigenetic regulation, gene expression, protein profiling and other important biological behaviours. Given an improved understanding of the relationship between early embryo development and tumourigenesis, now we have better and broader resources to attack cancer from the perspective of developmental biology and develop next generation of prognostic and therapeutic approaches for this devastating disease.

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