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Notch Signaling and Its Role in Breast Cancer

Overview
Journal Front Biosci
Specialty Biology
Date 2007 May 9
PMID 17485381
Citations 28
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Abstract

The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. In this review, we will focus on recent advancements in identification of aberrant Notch signaling in cancer, and the possible underlying mechanisms in breast cancer. We will also highlight the therapeutic potential of targeting Notch for cancer treatment.

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