The Immune System and the Gut Microbiota: Friends or Foes?

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2010 Sep 25

PMID 20865020

Citations 287

Authors

Nadine Cerf-Bensussan

Valerie Gaboriau-Routhiau

Affiliations

Soon will be listed here.

Abstract

The mammalian intestine is home to a complex community of trillions of bacteria that are engaged in a dynamic interaction with the host immune system. Determining the principles that govern host-microbiota relationships is the focus of intense research. Here, we describe how the intestinal microbiota is able to influence the balance between pro-inflammatory and regulatory responses and shape the host's immune system. We suggest that improving our understanding of the intestinal microbiota has therapeutic implications, not only for intestinal immunopathologies but also for systemic immune diseases.

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