Helicobacter Pylori: Gastric Cancer and Beyond

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2010 May 25

PMID 20495574

Citations 514

Authors

D Brent Polk

Richard M Peek Jr

Affiliations

Soon will be listed here.

Abstract

Helicobacter pylori is the dominant species of the human gastric microbiome, and colonization causes a persistent inflammatory response. H. pylori-induced gastritis is the strongest singular risk factor for cancers of the stomach; however, only a small proportion of infected individuals develop malignancy. Carcinogenic risk is modified by strain-specific bacterial components, host responses and/or specific host-microbe interactions. Delineation of bacterial and host mediators that augment gastric cancer risk has profound ramifications for both physicians and biomedical researchers as such findings will not only focus the prevention approaches that target H. pylori-infected human populations at increased risk for stomach cancer but will also provide mechanistic insights into inflammatory carcinomas that develop beyond the gastric niche.

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