Role of Ubiquitination in Endocytic Trafficking of G-protein-coupled Receptors

Overview

Journal Traffic

Publisher Wiley

Specialties Biology
Physiology

Date 2010 Sep 22

PMID 20854416

Citations 60

Authors

James N Hislop

Mark Von Zastrow

Affiliations

Soon will be listed here.

Abstract

Lysyl ubiquitination has long been known to target cytoplasmic proteins for proteasomal degradation, and there is now extensive evidence that ubiquitination functions in vacuolar/lysosomal targeting of membrane proteins from both the biosynthetic and endocytic pathways. G-protein-coupled receptors (GPCRs) represent the largest and most diverse family of membrane proteins, whose function is of fundamental importance both physiologically and therapeutically. In this review, we discuss the role of ubiquitination in the vacuolar/lysosomal downregulation of GPCRs through the endocytic pathway, with a primary focus on lysosomal trafficking in mammalian cells. We will summarize evidence indicating that mammalian GPCRs are regulated by ubiquitin-dependent mechanisms conserved in budding yeast, and then consider evidence for additional ubiquitin-dependent and -independent regulation that may be specific to animal cells.

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