James N Hislop
Overview
Explore the profile of James N Hislop including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
414
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0
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Recent Articles
1.
Jack C, Cope E, Lemel L, Canals M, Drube J, Hoffmann C, et al.
J Biol Chem
. 2024 Dec;
301(2):108112.
PMID: 39706266
The formyl-peptide receptor 2 (FPR2) is a G-protein-coupled receptor that responds to pathogen-derived peptides and regulates both proinflammatory and proresolution cellular processes. While ligand selectivity and G-protein signaling of FPR2...
2.
Steinmuller S, Tutov A, Hislop J, Decker M
ACS Chem Neurosci
. 2023 Oct;
14(20):3737-3744.
PMID: 37792463
The cannabinoid receptor 2 (CBR) has high, unexploited therapeutic potential in several central nervous system disorders due to its involvement in neuroinflammatory processes and pathologies like neurodegeneration. Dualsteric/bitopic ligands are...
3.
Steinmuller S, Fender J, Deventer M, Tutov A, Lorenz K, Stove C, et al.
Angew Chem Int Ed Engl
. 2023 Jun;
62(49):e202306176.
PMID: 37269130
The cannabinoid 2 receptor (CB R) has high therapeutic potential for multiple pathogenic processes, such as neuroinflammation. Pathway-selective ligands are needed to overcome the lack of clinical success and to...
4.
Rodriguez-Soacha D, Steinmuller S, Isbilir A, Fender J, Deventer M, Ramirez Y, et al.
ACS Chem Neurosci
. 2022 Jul;
13(16):2410-2435.
PMID: 35881914
Activation of the human cannabinoid receptor type 1 (CBR) with high spatiotemporal control is useful to study processes involved in different pathologies related to nociception, metabolic alterations, and neurological disorders....
5.
Zenko D, Thompson D, Hislop J
Neuropharmacology
. 2019 Oct;
162:107828.
PMID: 31654703
Cholinergic dysfunction plays a critical role in a number of disease states, and the loss of functional muscarinic acetylcholine receptors plays a key role in disease pathogenesis. Therefore, preventing receptor...
6.
Zenko D, Hislop J
Neuropharmacology
. 2017 Nov;
136(Pt C):374-382.
PMID: 29138081
Fidelity of signal transduction relies on cells expressing the appropriate number of functional receptors. Fluctuation in the total number of muscarinic acetylcholine receptors has been implicated in a range of...
7.
Thompson D, McArthur S, Hislop J, Flower R, Perretti M
J Biol Chem
. 2014 Oct;
289(52):36166-78.
PMID: 25326384
Formyl-peptide receptor type 2 (FPR2; also called ALX because it is the receptor for lipoxin A4) sustains a variety of biological responses relevant to the development and control of inflammation,...
8.
Hislop J, Islam T, Eleftheriadou I, Carpentier D, Trabalza A, Parkinson M, et al.
J Biol Chem
. 2014 Apr;
289(23):16148-63.
PMID: 24753246
Rabies pseudotyped lentiviral vectors have great potential in gene therapy, not least because of their ability to transduce neurons following their distal axonal application. However, very little is known about...
9.
Henry A, Hislop J, Grove J, Thorn K, Marsh M, Von Zastrow M
Dev Cell
. 2012 Sep;
23(3):519-32.
PMID: 22940114
Some endocytic cargoes control clathrin-coated pit (CCP) maturation, but it is not known how such regulation is communicated. We found that μ-opioid neuropeptide receptors signal to their enclosing CCPs by...
10.
Hislop J, Henry A, Von Zastrow M
J Biol Chem
. 2011 Sep;
286(46):40193-204.
PMID: 21953467
μ-Type opioid receptors (MORs) are members of the large seven-transmembrane receptor family which transduce the effects of both endogenous neuropeptides and clinically important opioid drugs. Prolonged activation of MORs promotes...