Network Interactions Explain Effective Encoding in the Context of Medial Temporal Damage in MCI

Overview

Journal Hum Brain Mapp

Publisher Wiley

Specialty Neurology

Date 2010 Sep 17

PMID 20845396

Citations 8

Authors

Andrea B Protzner

Jennifer L Mandzia

Sandra E Black

Mary Pat McAndrews

Affiliations

Soon will be listed here.

Abstract

Selective dysfunction in the medial temporal lobe (MTL) in amnestic mild cognitive impairment (MCI) results in a relatively circumscribed impairment in episodic memory. Previously, we found that activation extent in MTL during encoding correlated with subsequent recognition (hit rate) in controls but not in MCI patients (Mandzia et al. [2009]: Neurobiol Aging 30:717-730). Here, we examined whether functional connectivity amongst MTL and cortical regions might better explain differences in subsequent recognition success. Participants underwent fMRI scanning during picture encoding, and multivariate analysis was used to characterize the relationship between network activations and recognition. Both patients and controls activated a canonical MTL encoding network. However, this network correlated with hit rate only for controls. In MCI patients, recognition variability was best explained by the engagement of an additional network including BA 20. We propose that this pattern represents functional reorganization caused by reduced efficiency in the MTL network. Our findings suggest that understanding brain-behavior relationships in neurological disorders requires examination of large-scale networks, even when dysfunction is relatively focal as in MCI.

Citing Articles

Evaluating the Real-World Representativeness of Participants with Mild Cognitive Impairment in Canadian Research Protocols: a Comparison of the Characteristics of a Memory Clinic Patients and Research Samples.

Huang V, Hogan D, Ismail Z, Maxwell C, Smith E, Callahan B Can Geriatr J. 2020; 23(4):297-328.

PMID: 33282050 PMC: 7704078. DOI: 10.5770/cgj.23.416.

Patterns of effective connectivity during memory encoding and retrieval differ between patients with mild cognitive impairment and healthy older adults.

Hampstead B, Khoshnoodi M, Yan W, Deshpande G, Sathian K Neuroimage. 2015; 124(Pt A):997-1008.

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Mild cognitive impairment and fMRI studies of brain functional connectivity: the state of the art.

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