Mechanistic Insight into the Ability of American Ginseng to Suppress Colon Cancer Associated with Colitis

Overview

Journal Carcinogenesis

Specialty Oncology

Date 2010 Aug 24

PMID 20729391

Citations 23

Authors

Xiangli Cui

Yu Jin

Deepak Poudyal

Alexander A Chumanevich

Tia Davis

Anthony Windust

Anne Hofseth

Wensong Wu

Joshua Habiger

Edsel Pena

Patricia Wood

Mitzi Nagarkatti

Prakash S Nagarkatti

Lorne Hofseth

Affiliations

Soon will be listed here.

Abstract

We have recently shown that American ginseng (AG) prevents and treats mouse colitis. Because both mice and humans with chronic colitis have a high colon cancer risk, we tested the hypothesis that AG can be used to prevent colitis-driven colon cancer. Using the azoxymethane (AOM)/dextran sulfate sodium (DSS) mouse model of ulcerative colitis, we show that AG can suppress colon cancer associated with colitis. To explore the molecular mechanisms of the anticancer effects of AG, we also carried out antibody array experiments on colon cells isolated at a precancerous stage. We found there were 82 protein end points that were either significantly higher (41 proteins) or significantly lower (41 proteins) in the AOM + DSS group compared with the AOM-alone (control) group. In contrast, there were only 19 protein end points that were either significantly higher (10 proteins) or significantly lower (9 proteins) in the AOM + DSS + AG group compared with the AOM-alone (control) group. Overall, these results suggest that AG keeps the colon environment in metabolic equilibrium when mice are treated with AOM + DSS and gives insight into the mechanisms by which AG protects from colon cancer associated with colitis.

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