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Edsel Pena

Explore the profile of Edsel Pena including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 259
Followers 0
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Recent Articles
1.
Aksenova M, Sybrandt J, Cui B, Sikirzhytski V, Ji H, Odhiambo D, et al.
J Neuroimmune Pharmacol . 2019 Dec; 15(2):209-223. PMID: 31802418
HIV-1 Associated Neurocognitive Disorder (HAND) is a common and clinically detrimental complication of HIV infection. Viral proteins, including Tat, released from infected cells, cause neuronal toxicity. Substance abuse in HIV-infected...
2.
Abdalla A, West A, Jin Y, Saylor R, Qiang B, Pena E, et al.
J Neurochem . 2019 Aug; 153(1):33-50. PMID: 31419307
It is important to monitor serotonin neurochemistry in the context of brain disorders. Specifically, a better understanding of biophysical alterations and associated biochemical functionality within subregions of the brain will...
3.
Murphy K, Hendley M, Isely C, Annamalai P, Pena E, Gower R
ACS Appl Mater Interfaces . 2018 Nov; 10(50):43363-43374. PMID: 30462474
As biomaterial therapies emerge to address adipose tissue dysfunction that underlies metabolic disease, the immune response to these systems must be established. As a potential therapy, we are investigating resveratrol...
4.
Eberth J, Thibault A, Caldwell R, Josey M, Qiang B, Pena E, et al.
Cancer . 2018 Feb; 124(9):1912-1920. PMID: 29415338
Background: Cancer screening rates are lowest in those without insurance or a regular provider. Since 2008, the Colorectal Cancer Prevention Network (CCPN) has provided open access colonoscopy to uninsured residents...
5.
Abdalla A, Atcherley C, Pathirathna P, Samaranayake S, Qiang B, Pena E, et al.
Anal Chem . 2017 Aug; 89(18):9703-9711. PMID: 28795565
The mechanisms that control extracellular serotonin levels in vivo are not well-defined. This shortcoming makes it very challenging to diagnose and treat the many psychiatric disorders in which serotonin is...
6.
Oliver D, Ji H, Liu P, Gasparian A, Gardiner E, Lee S, et al.
Sci Rep . 2017 Feb; 7:43023. PMID: 28223711
Targeted cancer therapeutics aim to exploit tumor-specific, genetic vulnerabilities specifically affecting neoplastic cells without similarly affecting normal cells. Here we performed sequencing-based screening of an shRNA library on a panel...
7.
Chumanevich A, Chaparala A, Witalison E, Tashkandi H, Hofseth A, Lane C, et al.
Oncotarget . 2016 Dec; 8(1):228-237. PMID: 27974688
Ulcerative colitis (UC) is a chronic lifelong inflammatory disorder of the colon, which, while untreated, has a relapsing and remitting course with increasing risk of progression toward colorectal cancer. Current...
8.
Cui X, Jin Y, Poudyal D, Chumanevich A, Davis T, Windust A, et al.
Carcinogenesis . 2010 Aug; 31(10):1734-41. PMID: 20729391
We have recently shown that American ginseng (AG) prevents and treats mouse colitis. Because both mice and humans with chronic colitis have a high colon cancer risk, we tested the...
9.
Cui X, Jin Y, Hofseth A, Pena E, Habiger J, Chumanevich A, et al.
Cancer Prev Res (Phila) . 2010 Mar; 3(4):549-59. PMID: 20332304
Resveratrol is a naturally occurring polyphenol that exhibits pleiotropic health beneficial effects, including anti-inflammatory, cardio-protective, and cancer-protective activities. It is recognized as one of the more promising natural molecules in...
10.
Meeh P, Farrell C, Croshaw R, Crimm H, Miller S, Oroian D, et al.
Neoplasia . 2009 Oct; 11(10):1074-83. PMID: 19794966
We used digital long serial analysis of gene expression to discover gene expression differences between node-negative and node-positive colorectal tumors and developed a multigene classifier able to discriminate between these...