Noncoding RNPs of Viral Origin

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2010 Aug 20

PMID 20719877

Citations 17

Authors

Joan Steitz

Sumit Borah

Demian Cazalla

Victor Fok

Robin Lytle

Rachel Mitton-Fry

Kasandra Riley

Tasleem Samji

Affiliations

Soon will be listed here.

Abstract

Like their host cells, many viruses produce noncoding (nc)RNAs. These show diversity with respect to time of expression during viral infection, length and structure, protein-binding partners and relative abundance compared with their host-cell counterparts. Viruses, with their limited genomic capacity, presumably evolve or acquire ncRNAs only if they selectively enhance the viral life cycle or assist the virus in combating the host's response to infection. Despite much effort, identifying the functions of viral ncRNAs has been extremely challenging. Recent technical advances and enhanced understanding of host-cell ncRNAs promise accelerated insights into the RNA warfare mounted by this fascinating class of RNPs.

Citing Articles

Shaping the host cell environment with viral noncoding RNAs.

Gorbea C, Elhakiem A, Cazalla D Semin Cell Dev Biol. 2022; 146:20-30.

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A Long Non-Coding RNA of : Role in the Virus Interplay with the Host Immunity.

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Identification and formation mechanism of a novel noncoding RNA produced by avian infectious bronchitis virus.

An H, Cai Z, Yang Y, Wang Z, Liu D, Fang S Virology. 2019; 528:176-180.

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A comprehensive and quantitative exploration of thousands of viral genomes.

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miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1).

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