Demian Cazalla
Overview
Explore the profile of Demian Cazalla including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
918
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0
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Recent Articles
1.
Gorbea C, Elhakiem A, Cazalla D
Semin Cell Dev Biol
. 2022 Dec;
146:20-30.
PMID: 36581481
Just like the cells they infect viruses express different classes of noncoding RNAs (ncRNAs). Viral ncRNAs come in all shapes and forms, and they usually associate with cellular proteins that...
2.
Gorbea C, Elhakiem A, Cazalla D
Nucleic Acids Res
. 2022 Jun;
50(11):6511-6520.
PMID: 35648438
HSUR1 and HSUR2, two noncoding RNAs expressed by the oncogenic Herpesvirus saimiri, bind host microRNAs miR-142-3p, miR-16, and miR-27 with different purposes. While binding of miR-27 to HSUR1 triggers the...
3.
Cazalla D
Mamm Genome
. 2021 Sep;
33(2):412-420.
PMID: 34491378
Insights into interactions between viral factors and the cellular machinery usually lead to discoveries concerning host cell biology. Thus, the gene expression field has historically relied on viral model systems...
4.
Gorbea C, Mosbruger T, Nix D, Cazalla D
Elife
. 2019 Sep;
8.
PMID: 31538617
HSUR2 is a viral non-coding RNA (ncRNA) that functions as a microRNA (miRNA) adaptor. HSUR2 inhibits apoptosis in infected cells by recruiting host miRNAs miR-142-3p and miR-16 to mRNAs encoding...
5.
DePaula-Silva A, Gorbea C, Doty D, Libbey J, Sanchez J, Hanak T, et al.
J Neuroinflammation
. 2019 Jul;
16(1):152.
PMID: 31325960
Background: In the healthy central nervous system (CNS), microglia are found in a homeostatic state and peripheral macrophages are absent from the brain. Microglia play key roles in maintaining CNS...
6.
Cazalla D
RNA Biol
. 2018 Jun;
15(7):856-862.
PMID: 29895222
Viruses masterfully regulate host gene expression during infection. Many do so, in part, by expressing non-coding RNAs. Recent work has shown that HSUR 2, a viral non-coding RNA expressed by...
7.
Gorbea C, Mosbruger T, Cazalla D
Nature
. 2017 Oct;
550(7675):275-279.
PMID: 28976967
Viruses express several classes of non-coding RNAs; the functions and mechanisms by which most of these act are unknown. Herpesvirus saimiri, a γ-herpesvirus that establishes latency in the T cells...
8.
Giusti S, Vogl A, Brockmann M, Vercelli C, Rein M, Trumbach D, et al.
Elife
. 2014 Nov;
3.
PMID: 25406064
MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9...
9.
Maurin T, Cazalla D, Yang Jr S, Bortolamiol-Becet D, Lai E
RNA
. 2012 Oct;
18(12):2166-73.
PMID: 23097423
RNase III enzymes are fundamental to the biogenesis of microRNAs (miRNAs) and small interfering RNAs (siRNAs) in all species studied. Although alternative miRNA pathways independent of Drosha or Dicer exist,...
10.
Cazalla D, Xie M, Steitz J
Mol Cell
. 2011 Sep;
43(6):982-92.
PMID: 21925386
Herpesvirus saimiri (HVS) is a γ-herpesvirus that expresses Sm class U RNAs (HSURs) in latently infected marmoset T cells. By deep sequencing, we identified six HVS microRNAs (miRNAs) that are...