The Viral Latency-associated Nuclear Antigen Augments the B-cell Response to Antigen in Vivo

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2010 Aug 6

PMID 20686032

Citations 13

Authors

Sang-Hoon Sin

Farnaz D Fakhari

Dirk P Dittmer

Affiliations

Soon will be listed here.

Abstract

Gammaherpesviruses, including Kaposi sarcoma-associated herpesvirus (KSHV), establish latency in B cells. We hypothesized that the KSHV latency-associated nuclear antigen (LANA/orf73) provides a selective advantage to infected B cells by driving proliferation in response to antigen. To test this, we used LANA B-cell transgenic mice. Eight days after immunization with antigen without adjuvant, LANA mice had significantly more activated germinal center (GC) B cells (CD19(+) PNA(+) CD71(+)) than controls. This was dependent upon B-cell receptor since LANA did not restore the GC defect of CD19 knockout mice. However, LANA was able to restore the marginal zone defect in CD19 knockout mice.

Citing Articles

Mouse models of Kaposi sarcoma-associated herpesvirus (KSHV).

Shifflett K, Dittmer D Virology. 2025; 603:110384.

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The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice.

Sin S, Eason A, Kim Y, Schneider J, Damania B, Dittmer D Cell Host Microbe. 2024; 32(5):755-767.e4.

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Cancers associated with human gammaherpesviruses.

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Extracellular vesicles in virus infection and pathogenesis.

McNamara R, Dittmer D Curr Opin Virol. 2020; 44:129-138.

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Models of Oncoproteins Encoded by Kaposi's Sarcoma-Associated Herpesvirus.

Bravo Cruz A, Damania B J Virol. 2019; 93(11).

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