Sang-Hoon Sin
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Explore the profile of Sang-Hoon Sin including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Sin S, Eason A, Kim Y, Schneider J, Damania B, Dittmer D
Cell Host Microbe
. 2024 Apr;
32(5):755-767.e4.
PMID: 38653242
Kaposi sarcoma (KS) is the most common cancer in persons living with HIV. It is caused by KS-associated herpesvirus (KSHV). There exists no animal model for KS. Pronuclear injection of...
2.
Eason A, Sin S, Shah M, Yuan H, Phillips D, Droste M, et al.
PLoS One
. 2020 May;
15(5):e0233116.
PMID: 32407363
Kaposi Sarcoma (KS) is among the most angiogenic cancers in humans and an AIDS-defining condition. KS-associated herpesvirus (KSHV) is necessary for KS development, as is vascular endothelial growth factor (VEGF-A)....
3.
Sin S, Eason A, Bigi R, Kim Y, Kang S, Tan K, et al.
J Virol
. 2018 Jul;
92(19).
PMID: 30021906
Kaposi's sarcoma-associated herpesvirus (KSHV) induces B cell hyperplasia and neoplasia, such as multicentric Castleman's disease (MCD) and primary effusion lymphoma (PEL). To explore KSHV-induced B cell reprogramming , we expressed...
4.
Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human
Eason A, Sin S, Lin C, Damania B, Park S, Fedoriw Y, et al.
Oncotarget
. 2016 Aug;
7(39):63504-63513.
PMID: 27566574
Endemic Burkitt lymphoma (eBL) is primarily a childhood cancer in parts of Africa and Brazil. Classic studies describe eBL as a homogeneous entity based on t(8;14) IgH-Myc translocation and clinical...
5.
Sin S, Kang S, Kim Y, Eason A, Tan K, An H, et al.
J Virol
. 2015 Dec;
90(4):2150-4.
PMID: 26656696
Interleukin 6 (IL-6) is considered a proliferation and survival factor for B cells. To assess the role of IL-6 in Kaposi sarcoma-associated herpesvirus (KSHV) latency, KSHV latency locus-transgenic mice (referred...
6.
Dittmer D, Damania B, Sin S
Curr Opin Virol
. 2015 Oct;
14:145-50.
PMID: 26476352
Any one model system, be it culture or animal, only recapitulates one aspect of the viral life cycle in the human host. By providing recent examples of animal models for...
7.
Sin S, Kim Y, Eason A, Dittmer D
PLoS Pathog
. 2015 Sep;
11(9):e1005135.
PMID: 26327622
Kaposi sarcoma-associated herpesvirus (KSHV) has been linked to Kaposi sarcoma and B-cell malignancies. Mechanisms of KSHV-induced oncogenesis remain elusive, however, in part due to lack of reliable in vivo models....
8.
Sin S, Kim Y, Dittmer D
J Virol
. 2013 Aug;
87(21):11908-11.
PMID: 23966392
MicroRNA-155 (miR-155) is expressed in many cancers. It also executes evolutionary conserved functions in normal B cell development. We show that the Kaposi's sarcoma-associated herpesvirus (KSHV) latency locus, which contains...
9.
Chugh P, Sin S, Ozgur S, Henry D, Menezes P, Griffith J, et al.
PLoS Pathog
. 2013 Jul;
9(7):e1003484.
PMID: 23874201
MicroRNAs (miRNAs) are stable, small non-coding RNAs that modulate many downstream target genes. Recently, circulating miRNAs have been detected in various body fluids and within exosomes, prompting their evaluation as...
10.
Roy D, Sin S, Lucas A, Venkataramanan R, Wang L, Eason A, et al.
Cancer Res
. 2013 Feb;
73(7):2235-46.
PMID: 23382046
Kaposi sarcoma originates from endothelial cells and it is one of the most overt angiogenic tumors. In Sub-Saharan Africa, where HIV and the Kaposi sarcoma-associated herpesvirus (KSHV) are endemic, Kaposi...