Perinatal Morbidity After in Vitro Fertilization is Lower with Frozen Embryo Transfer

Overview

Journal Fertil Steril

Specialty Reproductive Medicine

Date 2010 Jul 29

PMID 20663500

Citations 37

Authors

Suleena Kansal Kalra

Sarah J Ratcliffe

Lauren Milman

Clarisa R Gracia

Christos Coutifaris

Kurt T Barnhart

Affiliations

Soon will be listed here.

Abstract

Objective: To study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis.

Design: Retrospective cohort study.

Setting: University-based infertility center, January 1998 to June 2006.

Patient(s): Two hundred eighteen IVF pregnancies after fresh embryo transfer (ET); 122 IVF pregnancies after frozen ET.

Intervention(s): Assessment of perinatal outcome in fresh versus frozen ET pregnancies.

Main Outcome Measure(s): Pregnancy outcomes after fresh versus frozen embryo transfer (ET). Primary outcome was a composite of three events: preterm delivery, intrauterine growth restriction, or low birth weight. Secondary outcomes were subtypes of pregnancy loss. Associations were assessed using multivariate logistic regression.

Result(s): The final sample included 340 pregnancies: 218 fresh and 122 frozen ETs. Singleton pregnancy was less likely after transfer of fresh embryos (odds ratio [OR] 0.39, 95% confidence interval [CI] 0.23-0.67), and pregnancies after fresh ET were more likely to end in first-trimester loss (OR 1.82, 95% CI 1.05-3.13). Composite adverse outcome after transfer of fresh (44.0%) versus frozen (32.6%) embryos was higher (OR 1.52, 95% CI 0.90-2.56) and was strongly associated with twin gestation (OR 23.82, 95% CI 11.16-50.82).

Conclusion(s): Perinatal morbidity is higher in IVF pregnancies conceived after a fresh ET compared with a frozen ET. Although some differences are related to conception with twin gestations, these findings suggest that adverse outcomes may be related to differences in IVF procedures.

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