Neuronal Progenitor Transplantation and Respiratory Outcomes Following Upper Cervical Spinal Cord Injury in Adult Rats

Overview

Journal Exp Neurol

Specialty Neurology

Date 2010 Jul 6

PMID 20599981

Citations 39

Authors

Todd E White

Michael A Lane

Milapjit S Sandhu

Barbara E OSteen

David D Fuller

Paul J Reier

Affiliations

Soon will be listed here.

Abstract

Despite extensive gray matter loss following spinal cord injury (SCI), little attention has been given to neuronal replacement strategies and their effects on specific functional circuits in the injured spinal cord. In the present study, we assessed breathing behavior and phrenic nerve electrophysiological activity following transplantation of microdissected dorsal or ventral pieces of rat fetal spinal cord tissue (FSC(D) or FSC(V), respectively) into acute, cervical (C2) spinal hemisections. Transneuronal tracing demonstrated connectivity between donor neurons from both sources and the host phrenic circuitry. Phrenic nerve recordings revealed differential effects of dorsally vs. ventrally derived neural progenitors on ipsilateral phrenic nerve recovery and activity. These initial results suggest that local gray matter repair can influence motoneuron function in targeted circuits following spinal cord injury and that outcomes will be dependent on the properties and phenotypic fates of the donor cells employed.

Citing Articles

Targeting Spinal Interneurons for Respiratory Recovery After Spinal Cord Injury.

Paracha M, Brezinski A, Singh R, Sinson E, Satkunendrarajah K Cells. 2025; 14(4).

PMID: 39996760 PMC: 11854602. DOI: 10.3390/cells14040288.

Combinatorial strategies for cell transplantation in traumatic spinal cord injury.

Jagrit V, Koffler J, Dulin J Front Neurosci. 2024; 18:1349446.

PMID: 38510468 PMC: 10951004. DOI: 10.3389/fnins.2024.1349446.

Implications of regional identity for neural stem and progenitor cell transplantation in the injured or diseased nervous system.

Kumar P, Dulin J Neural Regen Res. 2023; 19(4):715-716.

PMID: 37843199 PMC: 10664136. DOI: 10.4103/1673-5374.382236.

Contrasting Experimental Rodent Aftercare With Human Clinical Treatment for Cervical Spinal Cord Injury: Bridging the Translational "Valley of Death".

Silverstein A, Lawson K, Farhadi H, Alilain W J Neurotrauma. 2023; 40(23-24):2469-2486.

PMID: 37772694 PMC: 10698787. DOI: 10.1089/neu.2023.0314.

Differences in Anatomical Outcomes Between Early Chronic and Far Chronic Time-Points After Transplantation of Spinal Cord Neural Progenitor Cells in Mice.

Baltazar A, Tucker A, Jang J, Vo K, Dulin J J Neurotrauma. 2023; 40(23-24):2487-2499.

PMID: 37597207 PMC: 10698786. DOI: 10.1089/neu.2023.0264.

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