Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and Why?

Overview

Journal Cell Transplant

Specialties Cell Biology
General Surgery

Date 2019 Jan 19

PMID 30654638

Citations 13

Authors

Lyandysha V Zholudeva

Michael A Lane

Affiliations

Soon will be listed here.

Abstract

Cellular transplantation for repair of the injured spinal cord has a rich history with strategies focused on neuroprotection, immunomodulation, and neural reconstruction. The goal of the present review is to provide a concise overview and discussion of five key themes that have become important considerations for rebuilding functional neural networks. The questions raised include: (i) who are the donor cells selected for transplantation, (ii) what is the intended target for repair, (iii) when is the optimal time for transplantation, (iv) where should the cells be delivered, and lastly (v) why does cell transplantation remain an attractive candidate for promoting neural repair after injury? Recent developments in neurobiology and engineering now enable us to start addressing these questions with multidisciplinary expertise and methods.

Citing Articles

Bibliometric analysis of stem cells for spinal cord injury: current status and emerging frontiers.

Shang Z, Wanyan P, Wang M, Zhang B, Cui X, Wang X Front Pharmacol. 2023; 14:1235324.

PMID: 37533634 PMC: 10392836. DOI: 10.3389/fphar.2023.1235324.

Therapeutic Strategies Targeting Respiratory Recovery after Spinal Cord Injury: From Preclinical Development to Clinical Translation.

Michel-Flutot P, Lane M, Lepore A, Vinit S Cells. 2023; 12(11).

PMID: 37296640 PMC: 10252981. DOI: 10.3390/cells12111519.

Cell transplantation to repair the injured spinal cord.

Hall A, Fortino T, Spruance V, Niceforo A, Harrop J, Phelps P Int Rev Neurobiol. 2022; 166:79-158.

PMID: 36424097 PMC: 10008620. DOI: 10.1016/bs.irn.2022.09.008.

Diseased, differentiated and difficult: Strategies for improved engineering of neurological systems.

Elder N, Fattahi F, McDevitt T, Zholudeva L Front Cell Neurosci. 2022; 16:962103.

PMID: 36238834 PMC: 9550918. DOI: 10.3389/fncel.2022.962103.

Mesenchymal Stromal Cell Therapy in Spinal Cord Injury: Mechanisms and Prospects.

Xie J, Wang X, Li M, Tao Z, Teng W, Saijilafu Front Cell Neurosci. 2022; 16:862673.

PMID: 35722621 PMC: 9204037. DOI: 10.3389/fncel.2022.862673.

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