Remyelination of the Injured Spinal Cord

Overview

Journal Prog Brain Res

Publisher Elsevier

Specialty Neurology

Date 2007 Jul 10

PMID 17618995

Citations 11

Authors

Masanori Sasaki

Bingcang Li

Karen L Lankford

Christine Radtke

Jeffery D Kocsis

Affiliations

Soon will be listed here.

Abstract

Contusive spinal cord injury (SCI) can result in necrosis of the spinal cord, but often long white matter tracts outside of the central necrotic core are demyelinated. One experimental strategy to improve functional outcome following SCI is to transplant myelin-forming cells to remyelinate these axons and improve conduction. This review focuses on transplantation studies using olfactory ensheathing cell (OEC) to improve functional outcome in experimental models of SCI and demyelination. The biology of the OEC, and recent experimental research and clinical studies using OECs as a potential cell therapy candidate are discussed.

Citing Articles

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Selective adenosine A receptor inhibitor SCH58261 reduces oligodendrocyte loss upon brain injury in young rats.

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References

Jenkins S, Bennett V . Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. Proc Natl Acad Sci U S A. 2002; 99(4):2303-8. PMC: 122360. DOI: 10.1073/pnas.042601799. View

Lu J, Feron F, Mackay-Sim A, Waite P . Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain. 2002; 125(Pt 1):14-21. DOI: 10.1093/brain/awf014. View

Chuah M, West A . Cellular and molecular biology of ensheathing cells. Microsc Res Tech. 2002; 58(3):216-27. DOI: 10.1002/jemt.10151. View

Girault J, Peles E . Development of nodes of Ranvier. Curr Opin Neurobiol. 2002; 12(5):476-85. DOI: 10.1016/s0959-4388(02)00370-7. View

Au E, Roskams A . Olfactory ensheathing cells of the lamina propria in vivo and in vitro. Glia. 2003; 41(3):224-36. DOI: 10.1002/glia.10160. View

Keyvan-Fouladi N, Li Y, Raisman G . How do transplanted olfactory ensheathing cells restore function?. Brain Res Brain Res Rev. 2003; 40(1-3):325-7. DOI: 10.1016/s0165-0173(02)00215-1. View

Plant G, Christensen C, Oudega M, Bunge M . Delayed transplantation of olfactory ensheathing glia promotes sparing/regeneration of supraspinal axons in the contused adult rat spinal cord. J Neurotrauma. 2003; 20(1):1-16. DOI: 10.1089/08977150360517146. View

Hains B, Black J, Waxman S . Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. J Comp Neurol. 2003; 462(3):328-41. DOI: 10.1002/cne.10733. View

Senior K . Olfactory ensheathing cells to be used in spinal-cord repair trial. Lancet Neurol. 2003; 1(5):269. DOI: 10.1016/s1474-4422(02)00145-x. View

10.

Rios J, Rubin M, St Martin M, Downey R, Einheber S, Rosenbluth J . Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. J Neurosci. 2003; 23(18):7001-11. PMC: 6740666. View

11.

Keyvan-Fouladi N, Raisman G, Li Y . Functional repair of the corticospinal tract by delayed transplantation of olfactory ensheathing cells in adult rats. J Neurosci. 2003; 23(28):9428-34. PMC: 6740581. View

12.

Huang H, Chen L, Wang H, Xiu B, Li B, Wang R . Influence of patients' age on functional recovery after transplantation of olfactory ensheathing cells into injured spinal cord injury. Chin Med J (Engl). 2003; 116(10):1488-91. View

13.

Radtke C, Akiyama Y, Brokaw J, Lankford K, Wewetzer K, Fodor W . Remyelination of the nonhuman primate spinal cord by transplantation of H-transferase transgenic adult pig olfactory ensheathing cells. FASEB J. 2003; 18(2):335-7. PMC: 2605365. DOI: 10.1096/fj.03-0214fje. View

14.

Boyd J, Lee J, Skihar V, Doucette R, Kawaja M . LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord. Proc Natl Acad Sci U S A. 2004; 101(7):2162-6. PMC: 357069. DOI: 10.1073/pnas.0303842101. View

15.

Bareyre F, Kerschensteiner M, Raineteau O, Mettenleiter T, Weinmann O, Schwab M . The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci. 2004; 7(3):269-77. DOI: 10.1038/nn1195. View

16.

Rosenzweig E, McDonald J . Rodent models for treatment of spinal cord injury: research trends and progress toward useful repair. Curr Opin Neurol. 2004; 17(2):121-31. DOI: 10.1097/00019052-200404000-00007. View

17.

Ramer L, Au E, Richter M, Liu J, Tetzlaff W, Roskams A . Peripheral olfactory ensheathing cells reduce scar and cavity formation and promote regeneration after spinal cord injury. J Comp Neurol. 2004; 473(1):1-15. DOI: 10.1002/cne.20049. View

18.

Sasaki M, Lankford K, Zemedkun M, Kocsis J . Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin. J Neurosci. 2004; 24(39):8485-93. PMC: 2605369. DOI: 10.1523/JNEUROSCI.1998-04.2004. View

19.

Greenfield S, Brostoff S, Eylar E, Morell P . Protein composition of myelin of the peripheral nervous system. J Neurochem. 1973; 20(4):1207-16. DOI: 10.1111/j.1471-4159.1973.tb00089.x. View

20.

Gledhill R, McDonald W . Morphological characteristics of central demyelination and remyelination: a single-fiber study. Ann Neurol. 1977; 1(6):552-60. DOI: 10.1002/ana.410010607. View