Correlation of Serum Androgens with Anthropometric and Metabolic Indices in Healthy, Nonobese Postmenopausal Women

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2010 Jun 23

PMID 20566621

Citations 7

Authors

Peter R Casson

Michael J Toth

Julia V Johnson

Frank Z Stanczyk

Colleen L Casey

Marjorie E Dixon

Affiliations

Soon will be listed here.

Abstract

Objective: The role of testosterone in the regulation of metabolic and physiological function in men is well defined, but its role in women remains enigmatic. Thus, the present study sought to assess the contribution of endogenous circulating androgens to the regulation of metabolic function, body morphometry, and physical function in normal naturally postmenopausal women.

Methods: Using a cross-sectional design, we measured serum androgens in a cohort of 29 naturally postmenopausal women and correlated the results with metabolic, morphometric, and functional outcome parameters. These included insulin sensitivity, whole-body fat and lean body mass, visceral/abdominal fat areasm and aerobic capacity.

Results: Higher serum testosterone levels were related to greater maximal aerobic capacity and reduced adiposity. Additionally, higher serum dihydrotestosterone, dehydroepiandrosterone sulfate, androstenedione, and androstenetriol glucuronidate levels were correlated to greater insulin sensitivity.

Conclusion: In naturally postmenopausal women, endogenous androgens may play a role in the maintenance of beneficial patterns of metabolic, morphometric, and functional parameters.

Citing Articles

Percent body fat was negatively correlated with Testosterone levels in male.

Ma H, Sun J, Wu X, Mao J, Han Q PLoS One. 2024; 19(1):e0294567.

PMID: 38170701 PMC: 10763932. DOI: 10.1371/journal.pone.0294567.

Clinical Blood Metabogram: Application to Overweight and Obese Patients.

Lokhov P, Balashova E, Trifonova O, Maslov D, Plotnikova O, Sharafetdinov K Metabolites. 2023; 13(7).

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Cardiometabolic Risk Factors and Endogenous Sex Hormones in Postmenopausal Women: A Cross-Sectional Study.

Ottarsdottir K, Tivesten A, Li Y, Lindblad U, Hellgren M, Ohlsson C J Endocr Soc. 2022; 6(6):bvac050.

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Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies.

Rangel-Huerta O, Pastor-Villaescusa B, Gil A Metabolomics. 2019; 15(6):93.

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Androgens, body fat Distribution and Adipogenesis.

Zerradi M, Dereumetz J, Boulet M, Tchernof A Curr Obes Rep. 2015; 3(4):396-403.

PMID: 26626916 DOI: 10.1007/s13679-014-0119-6.

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