Changes over 14 Years in Androgenicity and Body Mass Index in a Biracial Cohort of Reproductive-age Women

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2008 Mar 13

PMID 18334590

Citations 10

Authors

Barbara Sternfeld

Kiang Liu

Charles P Quesenberry Jr

Hua Wang

Sheng-Fang Jiang

Martha Daviglus

Myriam Fornage

Cora E Lewis

John Mahan

Pamela J Schreiner

Stephen M Schwartz

Stephen Sidney

O Dale Williams

David S Siscovick

Affiliations

Soon will be listed here.

Abstract

Background: Body mass index (BMI) is directly related to testosterone (total T and free T) and inversely to SHBG cross-sectionally, but little is known about how changes in body fat and androgen markers affect each other over time.

Methods: Participants included 969 White and Black women from the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, who were ages 18-30 at entry into the study and were pre- or perimenopausal 16 yr later at the time of the CARDIA Women's Study (CWS). Total T and SHBG were assayed from specimens drawn at the CWS examination and stored serum from the yr 2 and 10 CARDIA exams. Free T was calculated based on total T and SHBG. BMI and waist circumference were measured at yr 2, 10, and 16.

Results: Despite clinically significant increases in BMI and waist circumference, total T and free T tended to decline, whereas SHBG remained relatively constant. BMI and waist circumference were directly correlated with free T and inversely correlated with SHBG in cross-sectional analyses. In longitudinal, multivariable analyses, an annualized increase in BMI was inversely related to a concurrent annualized decrease in SHBG (beta = -0.79 ng/dl, and se = 0.22 in Blacks; beta = -1.07 ng/dl; and se = 0.31 in Whites). However, early increases in BMI were not related to later decreases in SHBG.

Conclusion: Increases in adiposity are closely tied to decreases in SHBG, but changes in BMI and SHBG may occur concurrently rather than sequentially.

Citing Articles

Androgenicity in Young Women and Development of Metabolic Syndrome Before Menopause: The CARDIA and CARDIA Women's Studies.

Vu T, Pirzada A, Lewis C, Schreiner P, Liu K, Sternfeld B J Endocr Soc. 2024; 8(2):bvad174.

PMID: 38213908 PMC: 10783251. DOI: 10.1210/jendso/bvad174.

Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.

Kim C, Catov J, Schreiner P, Appiah D, Wellons M, Siscovick D J Am Heart Assoc. 2023; 12(5):e028132.

PMID: 36847077 PMC: 10111436. DOI: 10.1161/JAHA.122.028132.

Covariation of change in bioavailable testosterone and adiposity in midlife women.

Janssen I, Powell L, Jasielec M, Kazlauskaite R Obesity (Silver Spring). 2015; 23(2):488-494.

PMID: 25557490 PMC: 4310763. DOI: 10.1002/oby.20974.

Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women's Health Across the Nation.

Wildman R, Tepper P, Crawford S, Finkelstein J, Sutton-Tyrrell K, Thurston R J Clin Endocrinol Metab. 2012; 97(9):E1695-704.

PMID: 22723312 PMC: 3431568. DOI: 10.1210/jc.2012-1614.

Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?.

Giannoulis M, Martin F, Nair K, Umpleby A, Sonksen P Endocr Rev. 2012; 33(3):314-77.

PMID: 22433122 PMC: 5393154. DOI: 10.1210/er.2012-1002.

References

Haffner S, Valdez R, MORALES P, Hazuda H, Stern M . Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men. J Clin Endocrinol Metab. 1993; 77(1):56-60. DOI: 10.1210/jcem.77.1.8325960. View

PEARLMAN W, CREPY O, Murphy M . Testosterone-binding levels in the serum of women during the normal menstrual cycle, pregnancy, and the post-partum period. J Clin Endocrinol Metab. 1967; 27(7):1012-8. DOI: 10.1210/jcem-27-7-1012. View

Kopp H, Krzyzanowska K, Schernthaner G, Kriwanek S, Schernthaner G . Relationship of androgens to insulin resistance and chronic inflammation in morbidly obese premenopausal women: studies before and after vertical banded gastroplasty. Obes Surg. 2006; 16(9):1214-20. DOI: 10.1381/096089206778392130. View

Nestler J, Powers L, Matt D, Steingold K, Plymate S, Rittmaster R . A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J Clin Endocrinol Metab. 1991; 72(1):83-9. DOI: 10.1210/jcem-72-1-83. View

Raison J, Bonithon-Kopp C, Egloff M, Ducimetiere P, Guy-Grand B . Hormonal influences on the relationships between body fatness, body fat distribution, lipids, lipoproteins, glucose and blood pressure in French working women. Atherosclerosis. 1990; 85(2-3):185-92. DOI: 10.1016/0021-9150(90)90110-5. View

Lee C, Kasa-Vubu J, Supiano M . Androgenicity and obesity are independently associated with insulin sensitivity in postmenopausal women. Metabolism. 2004; 53(4):507-12. DOI: 10.1016/j.metabol.2003.10.018. View

Hughes G, Mathur R, Margolius H . Sex steroid hormones are altered in essential hypertension. J Hypertens. 1989; 7(3):181-7. View

Tchernof A, Toth M, Poehlman E . Sex hormone-binding globulin levels in middle-aged premenopausal women. Associations with visceral obesity and metabolic profile. Diabetes Care. 1999; 22(11):1875-81. DOI: 10.2337/diacare.22.11.1875. View

Falkner B, Sherif K, Sumner A, Kushner H . Hyperinsulinism and sex hormones in young adult African Americans. Metabolism. 1999; 48(1):107-12. DOI: 10.1016/s0026-0495(99)90018-5. View

10.

Ivandic A, Sucic M, Juric M . Hyperinsulinemia and sex hormones in healthy premenopausal women: relative contribution of obesity, obesity type, and duration of obesity. Metabolism. 1998; 47(1):13-9. DOI: 10.1016/s0026-0495(98)90186-x. View

11.

Lewis C, Smith D, Wallace D, Williams O, Bild D, Jacobs Jr D . Seven-year trends in body weight and associations with lifestyle and behavioral characteristics in black and white young adults: the CARDIA study. Am J Public Health. 1997; 87(4):635-42. PMC: 1380845. DOI: 10.2105/ajph.87.4.635. View

12.

Anderson D . Sex-hormone-binding globulin. Clin Endocrinol (Oxf). 1974; 3(1):69-96. DOI: 10.1111/j.1365-2265.1974.tb03298.x. View

13.

Berman D, Rodrigues L, Nicklas B, Ryan A, Dennis K, Goldberg A . Racial disparities in metabolism, central obesity, and sex hormone-binding globulin in postmenopausal women. J Clin Endocrinol Metab. 2001; 86(1):97-103. DOI: 10.1210/jcem.86.1.7147. View

14.

Dowling H, Pi-Sunyer F . Race-dependent health risks of upper body obesity. Diabetes. 1993; 42(4):537-43. View

15.

McTiernan A, Rajan K, Tworoger S, Irwin M, Bernstein L, Baumgartner R . Adiposity and sex hormones in postmenopausal breast cancer survivors. J Clin Oncol. 2003; 21(10):1961-6. PMC: 2996263. DOI: 10.1200/JCO.2003.07.057. View

16.

Feitosa M, Borecki I, Rankinen T, Leon A, Skinner J, Wilmore J . Lack of pleiotropic genetic effects between adiposity and sex hormone-binding globulin concentrations before and after 20 weeks of exercise training: the HERITAGE family study. Metabolism. 2003; 52(1):35-41. DOI: 10.1053/meta.2003.50004. View

17.

Haffner S . Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation. Int J Obes Relat Metab Disord. 2000; 24 Suppl 2:S56-8. DOI: 10.1038/sj.ijo.0801279. View

18.

Haffner S, Katz M, Dunn J . Increased upper body and overall adiposity is associated with decreased sex hormone binding globulin in postmenopausal women. Int J Obes. 1991; 15(7):471-8. View

19.

Sinha-Hikim I, Arver S, BEALL G, Shen R, Guerrero M, Sattler F . The use of a sensitive equilibrium dialysis method for the measurement of free testosterone levels in healthy, cycling women and in human immunodeficiency virus-infected women. J Clin Endocrinol Metab. 1998; 83(4):1312-8. DOI: 10.1210/jcem.83.4.4718. View

20.

Conway J, Yanovski S, Avila N, Hubbard V . Visceral adipose tissue differences in black and white women. Am J Clin Nutr. 1995; 61(4):765-71. DOI: 10.1093/ajcn/61.4.765. View