Percent Body Fat Was Negatively Correlated with Testosterone Levels in Male

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Jan 3

PMID 38170701

Authors

Hailu Ma

Juan Sun

Xueyan Wu

Jiangfeng Mao

Qin Han

Affiliations

Soon will be listed here.

Abstract

Background: Lower testosterone levels in men have been consistently associated with metabolic abnormalities, particularly obesity. This study aims to investigate the relationship between testosterone and obesity by analyzing the correlation between testosterone levels and body fat percentage using data from the NHANES (National Health and Nutrition Examination Survey) database.

Methods: The study included a total of 5959 participants from the NHANES 2011-2016. Multivariable linear regression models were used to assess the association between testosterone levels and body composition parameters, including total percent fat (TPF), android percent fat (APF), gynoid percent fat (GPF), android to gynoid ratio (A/G), and lean mass percent (LMP). Subgroup analyses stratified by sex were conducted using multivariable linear regression. To account for potential non-linear relationships, fitted smoothing curves and generalized additive models were utilized. A separate analysis of participants with a BMI ≥ 30 kg/m2 was conducted to validate the conclusions.

Result: Among males, testosterone levels showed a significant negative correlation with TPF (β = -11.97, P <0.0001), APF (β = -9.36, P<0.0001), GPF (β = -10.29, P <0.0001), and A/G (β = -320.93, P<0.0001), while a positive correlation was observed between LMP and testosterone levels (β = 12.62, P<0.0001). In females, a contrasting pattern emerged in the relationship between testosterone and body fat, but no significant correlation was found between testosterone and body composition in obese women.

Conclusions: The findings of this study support a negative association between body fat and testosterone levels in males.

Citing Articles

Impact of Weight Loss on Testosterone Levels: A Review of BMI and Testosterone.

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PMID: 39840189 PMC: 11745839. DOI: 10.7759/cureus.76139.

Difference in Body Composition Patterns between Age Groups in Italian Individuals with Overweight and Obesity: When BMI Becomes a Misleading Tool in Nutritional Settings.

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