Deregulated Expression of the Polycomb-group Protein SUZ12 Target Genes Characterizes Mantle Cell Lymphoma

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 2010 Jun 19

PMID 20558579

Citations 26

Authors

Daniel Martin-Perez

Esther Sanchez

Lorena Maestre

Javier Suela

Pierfrancesco Vargiu

Lorena Di Lisio

Nerea Martinez

Javier Alves

Miguel A Piris

Margarita Sanchez-Beato

Affiliations

Soon will be listed here.

Abstract

Polycomb proteins are known to be of great importance in human cancer pathogenesis. SUZ12 is a component of the Polycomb PRC2 complex that, along with EZH2, is involved in embryonic stem cell differentiation. EZH2 plays an essential role in many cancer types, but an equivalent involvement of SUZ12 has not been as thoroughly demonstrated. Here we show that SUZ12 is anomalously expressed in human primary tumors, especially in mantle cell lymphoma (MCL), pulmonary carcinomas and melanoma, and is associated with gene locus amplification in some cases. Using MCL as a model, functional and genomic studies demonstrate that SUZ12 loss compromises cell viability, increases apoptosis, and targets genes involved in central oncogenic pathways associated with MCL pathogenesis. Our results support the hypothesis that the abnormal expression of SUZ12 accounts for some of the unexplained features of MCL, such as abnormal DNA repair and increased resistance to apoptosis.

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