SUZ12 Promotes Gastric Cancer Cell Proliferation and Metastasis by Regulating KLF2 and E-cadherin

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2015 Feb 13

PMID 25672609

Citations 34

Authors

Rui Xia

Fei-yan Jin

Kai Lu

Li Wan

Min Xie

Tong-Peng Xu

Wei De

Zhao-Xia Wang

Affiliations

Soon will be listed here.

Abstract

SUZ12 is a core component of the polycomb repressive complex 2 (PRC2), which could silence gene transcription by generating trimethylation on lysine 27 residue of histone H3 (H3K27Me3). Meanwhile, SUZ12 has been found to be overexpressed in multiple cancers; however, the clinical significance and molecular mechanisms of SUZ12 controlling gastric cancer cell proliferation and metastasis are unclear. In this study, we found that SUZ12 expression was significantly increased in 64 gastric tumor tissues compared with normal tissues. Additionally, SUZ12 expression was associated with pathological stage, metastasis distance, and shorter overall survival of gastric cancer patients. Knockdown of SUZ12 expression impaired cell proliferation and invasion in vitro, leading to the inhibition of metastasis in vivo. Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT and KLF2 expression.

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