Ultrafast Assessment of Left Ventricular Dyssynchrony from Nuclear Myocardial Perfusion Imaging on a New High-speed Gamma Camera

Overview

Journal Eur J Nucl Med Mol Imaging

Specialties Biophysics
Nuclear Medicine
Radiology

Date 2010 Jun 18

PMID 20556604

Citations 22

Authors

Aju P Pazhenkottil

Ronny R Buechel

Bernhard A Herzog

Rene N Nkoulou

Ines Valenta

Ursula Fehlmann

Jelena-Rima Ghadri

Mathias Wolfrum

Lars Husmann

Philipp A Kaufmann

Affiliations

Soon will be listed here.

Abstract

Purpose: To validate the ultrafast assessment of left ventricular (LV) dyssynchrony by phase analysis using high-speed nuclear myocardial perfusion imaging (MPI) on a new gamma camera with cadmium-zinc-telluride (CZT) solid-state detector technology.

Methods: In 46 patients rest MPI with 960 MBq (99m)Tc-tetrofosmin was acquired on a dual-head detector SPECT camera (Ventri, GE Healthcare) and an ultrafast CZT camera (Discovery NM 530c, GE Healthcare) with acquisition times of 15 and 5 min, respectively. LV dyssynchrony was assessed using the Emory Cardiac Toolbox with established values for histogram bandwidth (male <62.4°; female <49.7°) and standard deviations (male <24.4°; female <22.1°) as the gold standard. Evaluating CZT scan times of 0.5, 1, 2, 3 and 5 min (list mode) in 16 patients revealed the preferred scan time to be 5 min, which was then applied in all 46 patients. Intraclass correlation and the level of agreement in dyssynchrony detection between the CZT and Ventri cameras were assessed.

Results: In LV dyssynchrony the mean histogram bandwidths with the CZT camera (n = 8) and the Ventri camera (n = 9) were 123.3 ± 50.6° and 130.2 ± 43.2° (p not significant) and 42.4 ± 13.6° vs. 43.2 ± 12.7° (p not significant). Normal bandwidths and SD obtained with the CZT camera (35.9 ± 7.7°, 12.6 ± 3.5°) and the Ventri camera (34.8 ± 6.6°, 11.1 ± 2.1°, both p not significant) excluded dyssynchrony in 38 and 37 patients, respectively. Intraclass correlation and the level of agreement between the CZT camera with a 5-min scan time and the Ventri camera were 0.94 (p < 0.001, SEE 14.4) and 96% for histogram bandwidth and 0.96 (p < 0.001, SEE 3.9) and 98% for SD.

Conclusion: This ultrafast CZT camera allows accurate assessment of LV dyssynchrony with a scan time of only 5 min, facilitating repeat measurements which would potentially be helpful for parameter optimization for cardiac resynchronization therapy.

Citing Articles

Relationship between left ventricular mechanical synchrony and left ventricular systolic function: a CZT-SPECT analysis.

Sun Q, Huang R, Fu S, Wu C, Guo X, Li T BMC Cardiovasc Disord. 2022; 22(1):420.

PMID: 36138379 PMC: 9494855. DOI: 10.1186/s12872-022-02863-8.

The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure.

Mishkina A, Saushkin V, Atabekov T, Sazonova S, Shipulin V, Massalha S J Nucl Cardiol. 2022; 30(1):371-382.

PMID: 35834158 DOI: 10.1007/s12350-022-03046-w.

A Left Ventricular Mechanical Dyssynchrony-Based Nomogram for Predicting Major Adverse Cardiac Events Risk in Patients With Ischemia and No Obstructive Coronary Artery Disease.

Zhang H, Shi K, Fei M, Fan X, Liu L, Xu C Front Cardiovasc Med. 2022; 9:827231.

PMID: 35369339 PMC: 8971375. DOI: 10.3389/fcvm.2022.827231.

Phase analysis single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) detects dyssynchrony in myocardial scar and increases specificity of MPI.

Bois J, Scott C, Chareonthaitawee P, Gibbons R, Rodriguez-Porcel M EJNMMI Res. 2019; 9(1):11.

PMID: 30706258 PMC: 6355889. DOI: 10.1186/s13550-019-0476-y.

Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT).

Peix A, Karthikeyan G, Massardo T, Kalaivani M, Patel C, Pabon L J Nucl Cardiol. 2019; 28(1):55-64.

PMID: 30684258 PMC: 7921049. DOI: 10.1007/s12350-018-01589-5.

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