Diet in Vitamin A Research

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2010 Jun 17

PMID 20552436

Citations 17

Authors

A Catharine Ross

Affiliations

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Abstract

A properly formulated diet is an essential underpinning for all in vivo research. This chapter focuses on the use of diet in retinoid research from two perspectives: human research, in which diet is usually variable and analysis of dietary intake is paramount to interpreting the study's results, and animal (rodent) research, in which diet is imposed as a factor in the experimental design, and the diet consumed is usually monotonous. Many standard rodent diets are nonpurified and the amount of vitamin A in the diet is unknown. Moreover, it is likely to be much higher than expected from the label. By using a well-formulated purified diet with an exact amount of vitamin A, retinoid status in rodents can be closely controlled to create specific physiological conditions that represent the wide range of vitamin A status present in human populations.

Citing Articles

Loss of the vitamin A receptor RBPR2 in mice disrupts whole-body retinoid homeostasis and the quantitative balance regulating retinylidene protein synthesis.

Radhakrishnan R, Leung M, Lor A, More S, Lobo G FASEB J. 2025; 39(5):e70407.

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Loss of the systemic vitamin A transporter RBPR2 affects the quantitative balance between chromophore and opsins in visual pigment synthesis.

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Vitamin A deficiency compromises the barrier function of the retinal pigment epithelium.

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