Th17 Cell Dynamics in HIV Infection

Overview

Journal Curr Opin HIV AIDS

Specialty Infectious Diseases

Date 2010 Jun 15

PMID 20543590

Citations 75

Authors

Nichole R Klatt

Jason M Brenchley

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Th17 cells are a newly identified subtype of CD4 T cells that respond to bacterial and fungal antigens and are important in mucosal immunology. Because HIV infection results in loss of CD4 T cells as well as disruption to the gastrointestinal tract that causes microbial translocation and immune activation, Th17 cells potentially play an important role in HIV pathogenesis. Here we examine the relationship between Th17 cells and HIV disease pathogenesis.

Recent Findings: Th17 cells are preferentially lost from the gastrointestinal tract of HIV-infected individuals, which is not entirely due to direct infection, as Th17 cells can be infected in vivo, but are not preferentially infected. Long-term highly active antiretroviral therapy (HAART) can result in restoration of Th17 cells in the gastrointestinal, which may be associated with better disease prognosis. Furthermore, other cells, such as Vdelta1 T cells, can make IL-17 in vivo during HIV infection and may contribute to antibacterial immunity after loss of Th17 cells.

Summary: Recent studies have improved our understanding of the role for Th17 cells during HIV infection; however, more studies are needed to discern better the detrimental consequences of loss of Th17 cells during HIV infection.

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References

Sumpter B, Dunham R, Gordon S, Engram J, Hennessy M, Kinter A . Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis. J Immunol. 2007; 178(3):1680-91. DOI: 10.4049/jimmunol.178.3.1680. View

Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan A . IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest. 2008; 118(2):534-44. PMC: 2157567. DOI: 10.1172/JCI33194. View

Chung D, Kasper D, Panzo R, Chitnis T, Grusby M, Sayegh M . CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol. 2003; 170(4):1958-63. DOI: 10.4049/jimmunol.170.4.1958. View

Fenoglio D, Poggi A, Catellani S, Battaglia F, Ferrera A, Setti M . Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. Blood. 2009; 113(26):6611-8. DOI: 10.1182/blood-2009-01-198028. View

Macal M, Sankaran S, Chun T, Reay E, Flamm J, Prindiville T . Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV-specific T-cell responses. Mucosal Immunol. 2008; 1(6):475-88. DOI: 10.1038/mi.2008.35. View

Nishimura Y, Brown C, Mattapallil J, Igarashi T, Buckler-White A, Lafont B . Resting naive CD4+ T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques. Proc Natl Acad Sci U S A. 2005; 102(22):8000-5. PMC: 1142395. DOI: 10.1073/pnas.0503233102. View

Maek-A-Nantawat W, Buranapraditkun S, Klaewsongkram J, Ruxrungtham K, Ruxrungthum K . Increased interleukin-17 production both in helper T cell subset Th17 and CD4-negative T cells in human immunodeficiency virus infection. Viral Immunol. 2007; 20(1):66-75. DOI: 10.1089/vim.2006.0063. View

Chen Y, Thai P, Zhao Y, Ho Y, DeSouza M, Wu R . Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop. J Biol Chem. 2003; 278(19):17036-43. DOI: 10.1074/jbc.M210429200. View

Schulz S, Kohler G, Holscher C, Iwakura Y, Alber G . IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance. Int Immunol. 2008; 20(9):1129-38. DOI: 10.1093/intimm/dxn069. View

10.

Wong C, Ho C, Li E, Lam C . Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus. 2000; 9(8):589-93. DOI: 10.1191/096120300678828703. View

11.

Brenchley J, Price D, Schacker T, Asher T, Silvestri G, Rao S . Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006; 12(12):1365-71. DOI: 10.1038/nm1511. View

12.

Raffatellu M, Santos R, Verhoeven D, George M, Wilson R, Winter S . Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat Med. 2008; 14(4):421-8. PMC: 2901863. DOI: 10.1038/nm1743. View

13.

Centlivre M, Sala M, Wain-Hobson S, Berkhout B . In HIV-1 pathogenesis the die is cast during primary infection. AIDS. 2006; 21(1):1-11. DOI: 10.1097/QAD.0b013e3280117f7f. View

14.

Ye P, Garvey P, Zhang P, Nelson S, Bagby G, Summer W . Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol. 2001; 25(3):335-40. DOI: 10.1165/ajrcmb.25.3.4424. View

15.

Lederman M, Penn-Nicholson A, Cho M, Mosier D . Biology of CCR5 and its role in HIV infection and treatment. JAMA. 2006; 296(7):815-26. DOI: 10.1001/jama.296.7.815. View

16.

Rudner X, Happel K, Young E, Shellito J . Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Infect Immun. 2007; 75(6):3055-61. PMC: 1932856. DOI: 10.1128/IAI.01329-06. View

17.

Favre D, Lederer S, Kanwar B, Ma Z, Proll S, Kasakow Z . Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 2009; 5(2):e1000295. PMC: 2635016. DOI: 10.1371/journal.ppat.1000295. View

18.

Wong C, Lit L, Shan Tam L, Li E, Wong P, Kei Lam C . Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol. 2008; 127(3):385-93. DOI: 10.1016/j.clim.2008.01.019. View

19.

Paiardini M, Cervasi B, Dunham R, Sumpter B, Radziewicz H, Silvestri G . Cell-cycle dysregulation in the immunopathogenesis of AIDS. Immunol Res. 2004; 29(1-3):253-68. DOI: 10.1385/IR:29:1-3:253. View

20.

Park H, Li Z, Yang X, Chang S, Nurieva R, Wang Y . A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005; 6(11):1133-41. PMC: 1618871. DOI: 10.1038/ni1261. View