The Remarkable Cochlear Amplifier

Overview

Journal Hear Res

Specialty Otorhinolaryngology

Date 2010 Jun 15

PMID 20541061

Citations 87

Authors

J Ashmore

P Avan

W E Brownell

P Dallos

K Dierkes

R Fettiplace

K Grosh

C M Hackney

A J Hudspeth

F Julicher

B Lindner

P MARTIN

J Meaud

C Petit

J Santos-Sacchi

J R Santos Sacchi

B Canlon

Affiliations

Soon will be listed here.

Abstract

This composite article is intended to give the experts in the field of cochlear mechanics an opportunity to voice their personal opinion on the one mechanism they believe dominates cochlear amplification in mammals. A collection of these ideas are presented here for the auditory community and others interested in the cochlear amplifier. Each expert has given their own personal view on the topic and at the end of their commentary they have suggested several experiments that would be required for the decisive mechanism underlying the cochlear amplifier. These experiments are presently lacking but if successfully performed would have an enormous impact on our understanding of the cochlear amplifier.

Citing Articles

Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.

Cai W, Grosh K Biophys J. 2024; 123(19):3421-3432.

PMID: 39148291 PMC: 11480764. DOI: 10.1016/j.bpj.2024.08.007.

Fast Inhibition Slows and Desynchronizes Mouse Auditory Efferent Neuron Activity.

Fischl M, Pederson A, Voglewede R, Cheng H, Drew J, Torres Cadenas L J Neurosci. 2024; 44(33).

PMID: 38937103 PMC: 11326868. DOI: 10.1523/JNEUROSCI.0382-24.2024.

On the interplay between speech perception and production: insights from research and theories.

Arjmandi M, Behroozmand R Front Neurosci. 2024; 18:1347614.

PMID: 38332858 PMC: 10850291. DOI: 10.3389/fnins.2024.1347614.

The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes.

Lazzeri G, Biagioni F, Ferrucci M, Puglisi-Allegra S, Lenzi P, Busceti C Int J Mol Sci. 2023; 24(23).

PMID: 38068993 PMC: 10706730. DOI: 10.3390/ijms242316664.

The role of GABA receptors in the subcortical pathways of the mammalian auditory system.

Turecek R, Melichar A, Kralikova M, Hruskova B Front Endocrinol (Lausanne). 2023; 14:1195038.

PMID: 37635966 PMC: 10456889. DOI: 10.3389/fendo.2023.1195038.

References

Zheng J, Deo N, Zou Y, Grosh K, Nuttall A . Chlorpromazine alters cochlear mechanics and amplification: in vivo evidence for a role of stiffness modulation in the organ of corti. J Neurophysiol. 2006; 97(2):994-1004. DOI: 10.1152/jn.00774.2006. View

Tinevez J, Julicher F, Martin P . Unifying the various incarnations of active hair-bundle motility by the vertebrate hair cell. Biophys J. 2007; 93(11):4053-67. PMC: 2084239. DOI: 10.1529/biophysj.107.108498. View

Zhao H, Santos-Sacchi J . Auditory collusion and a coupled couple of outer hair cells. Nature. 1999; 399(6734):359-62. DOI: 10.1038/20686. View

Rybalchenko V, Santos-Sacchi J . Cl- flux through a non-selective, stretch-sensitive conductance influences the outer hair cell motor of the guinea-pig. J Physiol. 2003; 547(Pt 3):873-91. PMC: 2342734. DOI: 10.1113/jphysiol.2002.036434. View

Ohmori H . Mechano-electrical transduction currents in isolated vestibular hair cells of the chick. J Physiol. 1985; 359:189-217. PMC: 1193371. DOI: 10.1113/jphysiol.1985.sp015581. View

Mellado Lagarde M, Drexl M, Lukashkina V, Lukashkin A, Russell I . Outer hair cell somatic, not hair bundle, motility is the basis of the cochlear amplifier. Nat Neurosci. 2008; 11(7):746-8. DOI: 10.1038/nn.2129. View

Bai J, Surguchev A, Montoya S, Aronson P, Santos-Sacchi J, Navaratnam D . Prestin's anion transport and voltage-sensing capabilities are independent. Biophys J. 2009; 96(8):3179-86. PMC: 2718310. DOI: 10.1016/j.bpj.2008.12.3948. View

Mammano F, Nobili R . Biophysics of the cochlea: linear approximation. J Acoust Soc Am. 1993; 93(6):3320-32. DOI: 10.1121/1.405716. View

Nobili R, Mammano F . Biophysics of the cochlea. II: Stationary nonlinear phenomenology. J Acoust Soc Am. 1996; 99(4 Pt 1):2244-55. DOI: 10.1121/1.415412. View

10.

Corey D, Hudspeth A . Kinetics of the receptor current in bullfrog saccular hair cells. J Neurosci. 1983; 3(5):962-76. PMC: 6564517. View

11.

Hudspeth A . Mechanoelectrical transduction by hair cells in the acousticolateralis sensory system. Annu Rev Neurosci. 1983; 6:187-215. DOI: 10.1146/annurev.ne.06.030183.001155. View

12.

Gueta R, Barlam D, Shneck R, Rousso I . Measurement of the mechanical properties of isolated tectorial membrane using atomic force microscopy. Proc Natl Acad Sci U S A. 2006; 103(40):14790-5. PMC: 1595430. DOI: 10.1073/pnas.0603429103. View

13.

Benser M, Marquis R, Hudspeth A . Rapid, active hair bundle movements in hair cells from the bullfrog's sacculus. J Neurosci. 1996; 16(18):5629-43. PMC: 6578960. View

14.

Chan D, Hudspeth A . Ca2+ current-driven nonlinear amplification by the mammalian cochlea in vitro. Nat Neurosci. 2005; 8(2):149-55. PMC: 2151387. DOI: 10.1038/nn1385. View

15.

Beurg M, Evans M, Hackney C, Fettiplace R . A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells. J Neurosci. 2006; 26(43):10992-1000. PMC: 6674673. DOI: 10.1523/JNEUROSCI.2188-06.2006. View

16.

Singh H, Cousin M, Ashley R . Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin. FEBS J. 2007; 274(24):6306-16. DOI: 10.1111/j.1742-4658.2007.06145.x. View

17.

Ryan A, Dallos P . Effect of absence of cochlear outer hair cells on behavioural auditory threshold. Nature. 1975; 253(5486):44-6. DOI: 10.1038/253044a0. View

18.

Santos-Sacchi J, Dilger J . Whole cell currents and mechanical responses of isolated outer hair cells. Hear Res. 1988; 35(2-3):143-50. DOI: 10.1016/0378-5955(88)90113-x. View

19.

Camalet S, Duke T, Julicher F, Prost J . Auditory sensitivity provided by self-tuned critical oscillations of hair cells. Proc Natl Acad Sci U S A. 2000; 97(7):3183-8. PMC: 16213. DOI: 10.1073/pnas.97.7.3183. View

20.

Engebretson A, ELDREDGE D . Model for the nonlinear characteristics of cochlear potentials. J Acoust Soc Am. 1968; 44(2):548-54. DOI: 10.1121/1.1911119. View