Attachment of Mouse Hepatitis Virus to O-acetylated Sialic Acid is Mediated by Hemagglutinin-esterase and Not by the Spike Protein

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2010 Jun 12

PMID 20538854

Citations 41

Authors

Martijn A Langereis

Arno L W van Vliet

Willemijn Boot

Raoul J de Groot

Affiliations

Soon will be listed here.

Abstract

The members of Betacoronavirus phylocluster A possess two types of surface projections, one comprised of the spike protein (S) and the other of hemagglutinin-esterase (HE). Purportedly, these viruses bind to O-acetylated sialic acids (O-Ac-Sias) primarily through S, with HE serving merely as receptor-destroying enzyme. Here, we show that, in apparent contrast to human and ungulate host range variants of Betacoronavirus-1, murine coronaviruses actually bind to O-Ac-Sias via HE exclusively. Apparently, expansion of group A betacoronaviruses into new hosts and niches was accompanied by changes in HE ligand and substrate preference and in the roles of HE and S in Sia receptor usage.

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