Raoul J de Groot
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Explore the profile of Raoul J de Groot including associated specialties, affiliations and a list of published articles.
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53
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3572
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Recent Articles
1.
Pronker M, Creutznacher R, Drulyte I, Hulswit R, Li Z, van Kuppeveld F, et al.
Nature
. 2023 Oct;
624(7990):201-206.
PMID: 37794193
Coronavirus spike proteins mediate receptor binding and membrane fusion, making them prime targets for neutralizing antibodies. In the cases of severe acute respiratory syndrome coronavirus, severe acute respiratory syndrome coronavirus...
2.
Aloise C, Schipper J, van Vliet A, Oymans J, Donselaar T, Hurdiss D, et al.
PLoS Pathog
. 2023 Aug;
19(8):e1011582.
PMID: 37607209
The nucleocapsid protein N of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enwraps and condenses the viral genome for packaging but is also an antagonist of the innate antiviral defense....
3.
Woo P, de Groot R, Haagmans B, Lau S, Neuman B, Perlman S, et al.
J Gen Virol
. 2023 Apr;
104(4).
PMID: 37097842
The family includes viruses with positive-sense RNA genomes of 22-36 kb that are expressed through a nested set of 3' co-terminal subgenomic mRNAs. Members of the subfamily are characterized by...
4.
Aloise C, Schipper J, de Groot R, van Kuppeveld F
Curr Opin Immunol
. 2022 Oct;
79:102254.
PMID: 36274340
Viruses, when entering their host cells, are met by a fierce intracellular immune defense. One prominent antiviral pathway is the integrated stress response (ISR). Upon activation of the ISR -...
5.
Wang C, Hesketh E, Shamorkina T, Li W, Franken P, Drabek D, et al.
Nat Commun
. 2022 May;
13(1):2921.
PMID: 35614127
Human coronavirus OC43 is a globally circulating common cold virus sustained by recurrent reinfections. How it persists in the population and defies existing herd immunity is unknown. Here we focus...
6.
Li Z, Liu L, Unione L, Lang Y, de Groot R, Boons G
ACS Infect Dis
. 2022 Apr;
8(5):1041-1050.
PMID: 35416033
A panel of -acetylated -glycolylneuraminic acid oligosaccharides has been prepared by diversification of common synthetic precursors by regioselective de--acetylation by coronaviral hemagglutinin-esterase (HE) combined with C7-to-C9 acetyl ester migration. The...
7.
Li Z, Unione L, Liu L, Lang Y, de Vries R, de Groot R, et al.
J Am Chem Soc
. 2021 Dec;
144(1):424-435.
PMID: 34967208
-Acetylation is a common modification of sialic acids that can occur at carbons 4-, 7-, 8-, and/or 9. Acetylated sialosides are employed as receptors by several betacoronaviruses and toroviruses, and...
8.
Li Z, Lang Y, Liu L, Bunyatov M, Sarmiento A, de Groot R, et al.
Nat Chem
. 2021 Mar;
13(5):496-503.
PMID: 33753916
The transmission of viruses from animal reservoirs to humans poses major threats to public health. Preparedness for future zoonotic outbreaks requires a fundamental understanding of how viruses of animal origin...
9.
Lang Y, Li W, Li Z, Koerhuis D, van den Burg A, Rozemuller E, et al.
Proc Natl Acad Sci U S A
. 2020 Sep;
117(41):25759-25770.
PMID: 32994342
Human coronaviruses OC43 and HKU1 are respiratory pathogens of zoonotic origin that have gained worldwide distribution. OC43 apparently emerged from a bovine coronavirus (BCoV) spillover. All three viruses attach to...
10.
Hurdiss D, Drulyte I, Lang Y, Shamorkina T, Pronker M, van Kuppeveld F, et al.
Nat Commun
. 2020 Sep;
11(1):4646.
PMID: 32938911
The human betacoronaviruses HKU1 and OC43 (subgenus Embecovirus) arose from separate zoonotic introductions, OC43 relatively recently and HKU1 apparently much longer ago. Embecovirus particles contain two surface projections called spike ...