Dynamin-like MxA GTPase: Structural Insights into Oligomerization and Implications for Antiviral Activity

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2010 Jun 12

PMID 20538602

Citations 51

Authors

Otto Haller

Song Gao

Alexander von der Malsburg

Oliver Daumke

Georg Kochs

Affiliations

Soon will be listed here.

Abstract

The interferon-inducible MxA GTPase is a key mediator of cell-autonomous innate immunity against a broad range of viruses such as influenza and bunyaviruses. MxA shares a similar domain structure with the dynamin superfamily of mechanochemical enzymes, including an N-terminal GTPase domain, a central middle domain, and a C-terminal GTPase effector domain. Recently, crystal structures of a GTPase domain dimer of dynamin 1 and of the oligomerized stalk of MxA (built by the middle and GTPase effector domains) were determined. These data provide exciting insights into the architecture and antiviral function of the MxA oligomer. Moreover, the structural knowledge paves the way for the development of novel antiviral drugs against influenza and other highly pathogenic viruses.

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