Genetic Mapping of the Mx Influenza Virus Resistance Gene Within the Region of Mouse Chromosome 16 That is Homologous to Human Chromosome 21

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1988 Nov 1

PMID 2902234

Citations 14

Authors

R H Reeves

B F OHara

W J Pavan

J D Gearhart

O Haller

Affiliations

Soon will be listed here.

Abstract

A total of 318 progeny from four backcrosses involving different laboratory strains and subspecies of Mus musculus were analyzed to map the Mx gene to the region of mouse chromosome 16 (MMU 16) which is homologous to human chromosome 21 (HSA 21). This result suggests that Mx will be found in the region of HSA 21 which has been implicated in Down syndrome when inherited in three copies.

Citing Articles

Mx genes: host determinants controlling influenza virus infection and trans-species transmission.

Haller O, Kochs G Hum Genet. 2019; 139(6-7):695-705.

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Host genetic determinants of influenza pathogenicity.

Lin T, Brass A Curr Opin Virol. 2013; 3(5):531-6.

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The role of host genetics in susceptibility to influenza: a systematic review.

Horby P, Nguyen N, Dunstan S, Baillie J PLoS One. 2012; 7(3):e33180.

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Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.

Haller O, Gao S, von der Malsburg A, Daumke O, Kochs G J Biol Chem. 2010; 285(37):28419-24.

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Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles.

Palm M, Garigliany M, Cornet F, Desmecht D Vet Res. 2010; 41(3):29.

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