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A Histoplasma Capsulatum-specific IgG1 Isotype Monoclonal Antibody, H1C, to a 70-kilodalton Cell Surface Protein is Not Protective in Murine Histoplasmosis

Overview
Journal Clin Vaccine Immunol
Publisher American Society for Microbiology
Specialties Allergy & Immunology
Pathology
Date 2010 May 21
PMID 20484567
Citations 11
Authors
Livia Cristina Liporagi Lopes
Allan J Guimaraes
Mariana Duarte de Cerqueira
Beatriz L Gomez
Joshua D Nosanchuk
Affiliations
Soon will be listed here.
Abstract

Monoclonal antibodies to Histoplasma capsulatum can modify pathogenesis. We now show that monoclonal antibody H1C to a 70-kDa antigen increases intracellular fungal growth and reduces macrophage nitric oxide release but has no effect on fungal burden or survival in murine infection. This further demonstrates the complexities of host-pathogen interactions.

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