Surface Architecture of Histoplasma Capsulatum

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2011 Nov 29

PMID 22121356

Citations 30

Authors

Allan J Guimaraes

Mariana D de Cerqueira

Joshua D Nosanchuk

Affiliations

Soon will be listed here.

Abstract

The dimorphic fungal pathogen Histoplasma capsulatum is the most frequent cause of clinically significant fungal pneumonia in humans. H. capsulatum virulence is achieved, in part, through diverse and dynamic alterations to the fungal cell surface. Surface components associated with H. capsulatum pathogenicity include carbohydrates, lipids, proteins, and melanins. Here, we describe the various structures comprising the cell surface of H. capsulatum that have been associated with virulence and discuss their involvement in the pathobiology of disease.

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References

Eissenberg L, Goldman W . Histoplasma variation and adaptive strategies for parasitism: new perspectives on histoplasmosis. Clin Microbiol Rev. 1991; 4(4):411-21. PMC: 358209. DOI: 10.1128/CMR.4.4.411. View

Rodrigues M, Nimrichter L, Oliveira D, Frases S, Miranda K, Zaragoza O . Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport. Eukaryot Cell. 2006; 6(1):48-59. PMC: 1800364. DOI: 10.1128/EC.00318-06. View

Habich C, Kempe K, van der Zee R, Burkart V, Kolb H . Different heat shock protein 60 species share pro-inflammatory activity but not binding sites on macrophages. FEBS Lett. 2002; 533(1-3):105-9. DOI: 10.1016/s0014-5793(02)03772-9. View

MELOAN E . Histoplasmosis. Miss Doct. 1952; 29(10):256-7. View

Nosanchuk J . Protective antibodies and endemic dimorphic fungi. Curr Mol Med. 2005; 5(4):435-42. DOI: 10.2174/1566524054022530. View

Long K, Gomez F, Morris R, Newman S . Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages. J Immunol. 2002; 170(1):487-94. DOI: 10.4049/jimmunol.170.1.487. View

Deepe Jr G . Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity. Clin Infect Dis. 2005; 41 Suppl 3:S204-7. DOI: 10.1086/429999. View

GOODWIN Jr R, DES PREZ R . State of the art: histoplasmosis. Am Rev Respir Dis. 1978; 117(5):929-56. DOI: 10.1164/arrd.1978.117.5.929. View

Albuquerque P, Nakayasu E, Rodrigues M, Frases S, Casadevall A, Zancope-Oliveira R . Vesicular transport in Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes. Cell Microbiol. 2008; 10(8):1695-710. PMC: 2562661. DOI: 10.1111/j.1462-5822.2008.01160.x. View

10.

Gomez B, Figueroa J, Hamilton A, Ortiz B, Robledo M, Restrepo A . Development of a novel antigen detection test for histoplasmosis. J Clin Microbiol. 1997; 35(10):2618-22. PMC: 230021. DOI: 10.1128/jcm.35.10.2618-2622.1997. View

11.

Howard D . Studies on the catalase of Histoplasma capsulatum. Infect Immun. 1983; 39(3):1161-6. PMC: 348078. DOI: 10.1128/iai.39.3.1161-1166.1983. View

12.

Wheat L . Laboratory diagnosis of histoplasmosis: update 2000. Semin Respir Infect. 2001; 16(2):131-40. DOI: 10.1053/srin.2001.24243. View

13.

Eissenberg L, Poirier S, Goldman W . Phenotypic variation and persistence of Histoplasma capsulatum yeasts in host cells. Infect Immun. 1996; 64(12):5310-4. PMC: 174524. DOI: 10.1128/iai.64.12.5310-5314.1996. View

14.

Domer J, Hamilton J, Harkin J . Comparative study of the cell walls of the yeastlike and mycelial phases of Histoplasma capsulatum. J Bacteriol. 1967; 94(2):466-74. PMC: 315061. DOI: 10.1128/jb.94.2.466-474.1967. View

15.

Zancope-Oliveira R, Morais E Silva Tavares P, Muniz M . Genetic diversity of Histoplasma capsulatum strains in Brazil. FEMS Immunol Med Microbiol. 2005; 45(3):443-9. DOI: 10.1016/j.femsim.2005.05.018. View

16.

Lipke P, Ovalle R . Cell wall architecture in yeast: new structure and new challenges. J Bacteriol. 1998; 180(15):3735-40. PMC: 107352. DOI: 10.1128/JB.180.15.3735-3740.1998. View

17.

Anjos A, Calvi S, Ferracini R, Peracoli M, Silva C, Soares A . Role of Paracoccidioides brasiliensis cell wall fraction containing beta-glucan in tumor necrosis factor-alpha production by human monocytes: correlation with fungicidal activity. Med Mycol. 2002; 40(4):377-82. DOI: 10.1080/mmy.40.4.377.382. View

18.

Santoro M . Heat shock factors and the control of the stress response. Biochem Pharmacol. 1999; 59(1):55-63. DOI: 10.1016/s0006-2952(99)00299-3. View

19.

Goodwin R, Loyd J, DES PREZ R . Histoplasmosis in normal hosts. Medicine (Baltimore). 1981; 60(4):231-66. DOI: 10.1097/00005792-198107000-00001. View

20.

Hamilton A, Bartholomew M, Figueroa J, Fenelon L, Hay R . Evidence that the M antigen of Histoplasma capsulatum var. capsulatum is a catalase which exhibits cross-reactivity with other dimorphic fungi. J Med Vet Mycol. 1990; 28(6):479-85. View