Vertebral Bone Marrow Fat is Positively Associated with Visceral Fat and Inversely Associated with IGF-1 in Obese Women

Overview

Journal Obesity (Silver Spring)

Specialties Endocrinology
Nutritional Sciences
Physiology

Date 2010 May 15

PMID 20467419

Citations 172

Authors

Miriam A Bredella

Martin Torriani

Reza Hosseini Ghomi

Bijoy J Thomas

Danielle J Brick

Anu V Gerweck

Clifford J Rosen

Anne Klibanski

Karen K Miller

Affiliations

Soon will be listed here.

Abstract

Recent studies have demonstrated an important physiologic link between bone and fat. Bone and fat cells arise from the same mesenchymal precursor cell within bone marrow, capable of differentiation into adipocytes or osteoblasts. Increased BMI appears to protect against osteoporosis. However, recent studies have suggested detrimental effects of visceral fat on bone health. Increased visceral fat may also be associated with decreased growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels which are important for maintenance of bone homeostasis. The purpose of our study was to assess the relationship between vertebral bone marrow fat and trabecular bone mineral density (BMD), abdominal fat depots, GH and IGF-1 in premenopausal women with obesity. We studied 47 premenopausal women of various BMI (range: 18-41 kg/m², mean 30 ± 7 kg/m²) who underwent vertebral bone marrow fat measurement with proton magnetic resonance spectroscopy (1H-MRS), body composition, and trabecular BMD measurement with computed tomography (CT), and GH and IGF-1 levels. Women with high visceral fat had higher bone marrow fat than women with low visceral fat. There was a positive correlation between bone marrow fat and visceral fat, independent of BMD. There was an inverse association between vertebral bone marrow fat and trabecular BMD. Vertebral bone marrow fat was also inversely associated with IGF-1, independent of visceral fat. Our study showed that vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 and BMD. This suggests that the detrimental effect of visceral fat on bone health may be mediated in part by IGF-1 as an important regulator of the fat and bone lineage.

Citing Articles

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References

Borkan G, Gerzof S, Robbins A, Hults D, Silbert C, Silbert J . Assessment of abdominal fat content by computed tomography. Am J Clin Nutr. 1982; 36(1):172-7. DOI: 10.1093/ajcn/36.1.172. View

Klein K, Larmore K, de Lancey E, Brown J, Considine R, Hassink S . Effect of obesity on estradiol level, and its relationship to leptin, bone maturation, and bone mineral density in children. J Clin Endocrinol Metab. 1998; 83(10):3469-75. DOI: 10.1210/jcem.83.10.5204. View

Takada I, Suzawa M, Matsumoto K, Kato S . Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci. 2007; 1116:182-95. DOI: 10.1196/annals.1402.034. View

Rosen C, Ackert-Bicknell C, Adamo M, Shultz K, Rubin J, Donahue L . Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone. 2004; 35(5):1046-58. DOI: 10.1016/j.bone.2004.07.008. View

Provencher S . Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993; 30(6):672-9. DOI: 10.1002/mrm.1910300604. View

Shen W, Chen J, Punyanitya M, Shapses S, Heshka S, Heymsfield S . MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women. Osteoporos Int. 2006; 18(5):641-7. PMC: 2034514. DOI: 10.1007/s00198-006-0285-9. View

Rexrode K, Carey V, Hennekens C, Walters E, Colditz G, Stampfer M . Abdominal adiposity and coronary heart disease in women. JAMA. 1998; 280(21):1843-8. DOI: 10.1001/jama.280.21.1843. View

Pijl H, Langendonk J, Burggraaf J, Frolich M, Cohen A, Veldhuis J . Altered neuroregulation of GH secretion in viscerally obese premenopausal women. J Clin Endocrinol Metab. 2001; 86(11):5509-15. DOI: 10.1210/jcem.86.11.8061. View

Vikman K, Isgaard J, Eden S . Growth hormone regulation of insulin-like growth factor-I mRNA in rat adipose tissue and isolated rat adipocytes. J Endocrinol. 1991; 131(1):139-45. DOI: 10.1677/joe.0.1310139. View

10.

Miller K, Biller B, Lipman J, Bradwin G, Rifai N, Klibanski A . Truncal adiposity, relative growth hormone deficiency, and cardiovascular risk. J Clin Endocrinol Metab. 2004; 90(2):768-74. DOI: 10.1210/jc.2004-0894. View

11.

Papakitsou E, Margioris A, Dretakis K, Trovas G, Zoras U, Lyritis G . Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women. Maturitas. 2004; 47(3):185-93. DOI: 10.1016/S0378-5122(03)00282-2. View

12.

Moerman E, Teng K, Lipschitz D, Lecka-Czernik B . Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell. 2004; 3(6):379-89. PMC: 1850101. DOI: 10.1111/j.1474-9728.2004.00127.x. View

13.

Giustina A, Mazziotti G, Canalis E . Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev. 2008; 29(5):535-59. PMC: 2726838. DOI: 10.1210/er.2007-0036. View

14.

Gevers E, Loveridge N, Robinson I . Bone marrow adipocytes: a neglected target tissue for growth hormone. Endocrinology. 2002; 143(10):4065-73. DOI: 10.1210/en.2002-220428. View

15.

Rosen C . Bone remodeling, energy metabolism, and the molecular clock. Cell Metab. 2008; 7(1):7-10. DOI: 10.1016/j.cmet.2007.12.004. View

16.

Mukherjee A, Murray R, Shalet S . Impact of growth hormone status on body composition and the skeleton. Horm Res. 2004; 62 Suppl 3:35-41. DOI: 10.1159/000080497. View

17.

Makimura H, Stanley T, Mun D, You S, Grinspoon S . The effects of central adiposity on growth hormone (GH) response to GH-releasing hormone-arginine stimulation testing in men. J Clin Endocrinol Metab. 2008; 93(11):4254-60. PMC: 2582562. DOI: 10.1210/jc.2008-1333. View

18.

Schellinger D, Lin C, Hatipoglu H, Fertikh D . Potential value of vertebral proton MR spectroscopy in determining bone weakness. AJNR Am J Neuroradiol. 2001; 22(8):1620-7. PMC: 7974571. View

19.

Bredella M, Torriani M, Thomas B, Hosseini Ghomi R, Brick D, Gerweck A . Peak growth hormone-releasing hormone-arginine-stimulated growth hormone is inversely associated with intramyocellular and intrahepatic lipid content in premenopausal women with obesity. J Clin Endocrinol Metab. 2009; 94(10):3995-4002. PMC: 2758723. DOI: 10.1210/jc.2009-0438. View

20.

Hwu C, Kwok C, Lai T, Shih K, Lee T, Hsiao L . Growth hormone (GH) replacement reduces total body fat and normalizes insulin sensitivity in GH-deficient adults: a report of one-year clinical experience. J Clin Endocrinol Metab. 1997; 82(10):3285-92. DOI: 10.1210/jcem.82.10.4311. View