Peripheral Biomarkers of Endometriosis: a Systematic Review

Overview

Journal Hum Reprod Update

Specialty Reproductive Medicine

Date 2010 May 14

PMID 20462942

Citations 115

Authors

K E May

S A Conduit-Hulbert

J Villar

S Kirtley

S H Kennedy

C M Becker

Affiliations

Soon will be listed here.

Abstract

Background: Endometriosis is estimated to affect 1 in 10 women during the reproductive years. There is often delay in making the diagnosis, mainly due to the non-specific nature of the associated symptoms and the need to verify the disease surgically. A biomarker that is simple to measure could help clinicians to diagnose (or at least exclude) endometriosis; it might also allow the effects of treatment to be monitored. If effective, such a marker or panel of markers could prevent unnecessary diagnostic procedures and/or recognize treatment failure at an early stage.

Methods: We used QUADAS (Quality Assessment of Diagnostic Accuracy Studies) criteria to perform a systematic review of the literature over the last 25 years to assess critically the clinical value of all proposed biomarkers for endometriosis in serum, plasma and urine.

Results: We identified over 100 putative biomarkers in publications that met the selection criteria. We were unable to identify a single biomarker or panel of biomarkers that have unequivocally been shown to be clinically useful.

Conclusions: Peripheral biomarkers show promise as diagnostic aids, but further research is necessary before they can be recommended in routine clinical care. Panels of markers may allow increased sensitivity and specificity of any diagnostic test.

Citing Articles

Altered Mitochondrial Morphology and Reduced Cardiolipin Levels in Oocytes of Endometriosis Model Mice: Implications for Mitochondrial Dysfunction in Infertility.

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Integration of Single Cell and Bulk RNA-Sequencing Reveals Key Genes and Immune Cell Infiltration to Construct a Predictive Model and Identify Drug Targets in Endometriosis.

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Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study.

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Multidimensional landscape of non-alcoholic fatty liver disease-related disease spectrum uncovered by big omics data: Profiling evidence and new perspectives.

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A Preliminary Investigation of the Roles of Endometrial Cells in Endometriosis Development via In Vitro and In Vivo Analyses.

Cheng Y, Huang C, Lien H, Hsiao Y, Weng P, Chang Y Int J Mol Sci. 2024; 25(7).

PMID: 38612685 PMC: 11011664. DOI: 10.3390/ijms25073873.

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