Association of Polymorphisms in the BDNF, DRD1 and DRD3 Genes with Tobacco Smoking in Schizophrenia

Overview

Journal Ann Hum Genet

Date 2010 May 12

PMID 20456319

Citations 28

Authors

Gabriela Novak

Martha LeBlanc

Clement Zai

Sajid Shaikh

Julien Renou

Vincenzo Deluca

Natalie Bulgin

James L Kennedy

Bernard Le Foll

Affiliations

Soon will be listed here.

Abstract

Emerging evidence indicates that the DRD1-BDNF-DRD3 cluster plays an important role in nicotine addiction. We have performed an association analysis of 42 SNPs within these genes with cigarette consumption in a group of 341 schizophrenia patients. The ACCG haplotype consisting of four BDNF markers (Val66Met (rs6265), rs11030104, rs2049045 and rs7103411) showed an association with the risk of smoking (p = 0.0002). Both DRD1 markers tested (rs4532 and rs686) and the DRD3 marker (rs1025398) showed association with quantity of tobacco smoked (p = 0.01, 0.005 and 0.002, respectively). Our findings are preliminary; however, they support the involvement of the DRD1, BDNF and DRD3 genes in smoking behaviour.

Citing Articles

Dopaminergic Epistases in Schizophrenia.

Bosun A, Albu-Kalinovic R, Neda-Stepan O, Bosun I, Farcas S, Enatescu V Brain Sci. 2024; 14(11).

PMID: 39595853 PMC: 11592377. DOI: 10.3390/brainsci14111089.

Associations between polygenic risk scores and accelerated brain ageing in smokers.

Yang Z, Zhao W, LinLi Z, Guo S, Feng J Psychol Med. 2023; 53(16):7785-7794.

PMID: 37555321 PMC: 10755245. DOI: 10.1017/S0033291723001812.

Smoking Genes: A Case-Control Study of Dopamine Transporter Gene () and Dopamine Receptor Genes (, and ) Polymorphisms and Smoking Behaviour in a Malay Male Cohort.

Ruzilawati A, Islam M, Muhamed S, Ahmad I Biomolecules. 2020; 10(12).

PMID: 33287325 PMC: 7761729. DOI: 10.3390/biom10121633.

Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors.

Ma Y, Li J, Xu Y, Wang Y, Yao Y, Liu Q Aging (Albany NY). 2020; 12(3):2169-2225.

PMID: 32012119 PMC: 7041787. DOI: 10.18632/aging.102735.

Meta-analytic method reveal a significant association of theBDNF Val66Met variant with smoking persistence based on a large samples.

Zhao H, Xiong S, Li Z, Wu X, Li L Pharmacogenomics J. 2019; 20(3):398-407.

PMID: 31787753 PMC: 7253357. DOI: 10.1038/s41397-019-0124-y.