Isolation and Characterization of a New Ginsenoside from the Fresh Root of Panax Ginseng

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2010 Apr 30

PMID 20428044

Citations 19

Authors

Chang-Chun Ruan

Zhi Liu

Xiang Li

Xia Liu

Li-Juan Wang

Hong-Yu Pan

Yi-Nan Zheng

Guang-Zhi Sun

Yan-Sheng Zhang

Lian-Xue Zhang

Affiliations

Soon will be listed here.

Abstract

A new saponin, malonylginsenoside Ra3, was isolated from the fresh root of Panax ginseng, along with four known ginsenosides. The new compound was identified as (20S)-protopanaxadiol-3-O-(6-O-malonyl-beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranoside-20-O-beta-D-xylopyranosyl(1-->3)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis.

Citing Articles

Rare ginsenosides transformed from stems and leaves of reverse obesity by promoting browning of white fat through PKA/CREB pathway via REGγ negative regulation.

Chen J, Sha J, Huo X, Li Z, Qu D, Li X J Ginseng Res. 2025; 49(2):156-165.

PMID: 40061479 PMC: 11889382. DOI: 10.1016/j.jgr.2024.11.005.

Research progress on chemical diversity of saponins in .

Geng X, Wang J, Liu Y, Liu L, Liu X, Zhao Y Chin Herb Med. 2024; 16(4):529-547.

PMID: 39606259 PMC: 11589341. DOI: 10.1016/j.chmed.2024.08.005.

Identification and analysis of BAHD superfamily related to malonyl ginsenoside biosynthesis in .

Wang P, Yan Y, Yan M, Piao X, Wang Y, Lei X Front Plant Sci. 2024; 14:1301084.

PMID: 38186598 PMC: 10768564. DOI: 10.3389/fpls.2023.1301084.

Diversity of Ginsenoside Profiles Produced by Various Processing Technologies.

Piao X, Huo Y, Kang J, Mathiyalagan R, Zhang H, Yang D Molecules. 2020; 25(19).

PMID: 32987784 PMC: 7582514. DOI: 10.3390/molecules25194390.

Advances in Saponin Diversity of .

Piao X, Zhang H, Kang J, Yang D, Li Y, Pang S Molecules. 2020; 25(15).

PMID: 32751233 PMC: 7435442. DOI: 10.3390/molecules25153452.

References

Yamaguchi H, Kasai R, Matsuura H, Tanaka O, Fuwa T . High-performance liquid chromatographic analysis of acidic saponins of ginseng and related plants. Chem Pharm Bull (Tokyo). 1988; 36(9):3468-73. DOI: 10.1248/cpb.36.3468. View

Xiang Y, Shang H, Gao X, Zhang B . A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res. 2008; 22(7):851-8. DOI: 10.1002/ptr.2384. View

Ruan C, Zhang H, Zhang L, Liu Z, Sun G, Lei J . Biotransformation of ginsenoside Rf to Rh1 by recombinant beta-glucosidase. Molecules. 2009; 14(6):2043-8. PMC: 6254368. DOI: 10.3390/molecules14062043. View

Yue P, Mak N, Cheng Y, Leung K, Ng T, Fan D . Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med. 2007; 2:6. PMC: 1876803. DOI: 10.1186/1749-8546-2-6. View

Bachran C, Bachran S, Sutherland M, Bachran D, Fuchs H . Saponins in tumor therapy. Mini Rev Med Chem. 2008; 8(6):575-84. DOI: 10.2174/138955708784534445. View

Liu Z, Wang L, Li X, Hu J, Chen Y, Ruan C . Hypoglycemic effects of malonyl-ginsenosides extracted from roots of Panax ginseng on streptozotocin-induced diabetic mice. Phytother Res. 2009; 23(10):1426-30. DOI: 10.1002/ptr.2796. View

Li X, Liu Z, Zhang X, Wang L, Zheng Y, Yuan C . Isolation and characterization of phenolic compounds from the leaves of Salix matsudana. Molecules. 2008; 13(8):1530-7. PMC: 6245188. DOI: 10.3390/molecules13081530. View

Li X, Liu Z, Chen Y, Wang L, Zheng Y, Sun G . Rubiacordone A: a new anthraquinone glycoside from the roots of Rubia cordifolia. Molecules. 2009; 14(1):566-72. PMC: 6253770. DOI: 10.3390/molecules14010566. View

Tung N, Song G, Park Y, Kim Y . Two new dammarane-type saponins from the leaves of Panax ginseng. Chem Pharm Bull (Tokyo). 2009; 57(12):1412-4. DOI: 10.1248/cpb.57.1412. View

10.

Wang J, Li X, Zheng Y, Yang X . Isoginsenoside-Rh3, a new triterpenoid saponin from the fruits of Panax ginseng C. A. Mey. J Asian Nat Prod Res. 2004; 6(4):289-93. DOI: 10.1080/10286020310001595980. View

11.

Lei J, Li X, Gong X, Zheng Y . Isolation, synthesis and structures of cytotoxic ginsenoside derivatives. Molecules. 2007; 12(9):2140-50. PMC: 6149086. DOI: 10.3390/12092140. View