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Rubiacordone A: a New Anthraquinone Glycoside from the Roots of Rubia Cordifolia

Overview
Journal Molecules
Publisher MDPI
Specialty Biology
Date 2009 Jan 27
PMID 19169203
Citations 6
Authors
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Abstract

A new anthraquinone, Rubiacordone A (1) (6-acetoxy-1-hydroxy-2-methylanthraquinone-3-O-alpha-L-rhamnopyranoside), was isolated together with the known anthraquinone, 1-acetoxy-6-hydroxy-2-methylanthraquinone-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside] (2), from the dried roots of Rubia cordifolia. Their structures were elucidated on the basis of extensive 1D and 2D-NMR, as well as HRESI-MS spectroscopic analysis. Metabolites 1 and 2 showed considerable antimicrobial activity against Gram-positive bacteria.

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References
1.
Tao J, Morikawa T, Ando S, Matsuda H, Yoshikawa M . Bioactive constituents from Chinese natural medicines. XI. inhibitors on NO production and degranulation in RBL-2H3 from Rubia yunnanensis: structures of rubianosides II, III, and IV, rubianol-g, and rubianthraquinone. Chem Pharm Bull (Tokyo). 2003; 51(6):654-62. DOI: 10.1248/cpb.51.654. View

2.
Cai Y, Sun M, Xing J, Corke H . Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships. J Agric Food Chem. 2004; 52(26):7884-90. DOI: 10.1021/jf0489116. View

3.
Lee J, Hitotsuyanagi Y, Kim I, Hasuda T, Takeya K . A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: structure, semi-synthesis, and cytotoxicity. Bioorg Med Chem Lett. 2007; 18(2):808-11. DOI: 10.1016/j.bmcl.2007.11.030. View

4.
Son J, Jung S, Jung J, Fang Z, Lee C, Seo C . Anticancer constituents from the roots of Rubia cordifolia L. Chem Pharm Bull (Tokyo). 2008; 56(2):213-6. DOI: 10.1248/cpb.56.213. View