Intravital Imaging Illuminates Transforming Growth Factor Beta Signaling Switches During Metastasis

Overview

Journal Cancer Res

Specialty Oncology

Date 2010 Apr 29

PMID 20424121

Citations 32

Authors

Silvia Giampieri

Sophie Pinner

Erik Sahai

Affiliations

Soon will be listed here.

Abstract

Transforming growth factor beta (TGFbeta) has seemingly contradictory roles in tumor progression: it can promote metastatic invasion but also act as a tumor suppressor. Recently, two studies have used intravital imaging to unravel the role of TGFbeta at different stages of the metastatic process. TGFbeta promotes single cell motility, which enables invasion into blood vessels. However the activation of TGFbeta signaling is a transient event and is not maintained at distant sites. The downregulation of TGFbeta signaling at secondary sites then permits growth of secondary tumors. In the absence of TGFbeta, cells are restricted to collective movement and lymphatic spread. Here, we discuss these findings and their potential implications.

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