Measurement and Modeling of Signaling at the Single-cell Level

Overview

Journal Biochemistry

Specialty Biochemistry

Date 2012 Sep 8

PMID 22954137

Citations 16

Authors

Sarah E Kolitz

Douglas A Lauffenburger

Affiliations

Soon will be listed here.

Abstract

It has long been recognized that a deeper understanding of cell function, with respect to execution of phenotypic behaviors and their regulation by the extracellular environment, is likely to be achieved by analyzing the underlying molecular processes for individual cells selected from across a population, rather than averages of many cells comprising that population. In recent years, experimental and computational methods for undertaking these analyses have advanced rapidly. In this review, we provide a perspective on both measurement and modeling facets of biochemistry at a single-cell level. Our central focus is on receptor-mediated signaling networks that regulate cell phenotypic functions.

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