Classifying Collective Cancer Cell Invasion

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2012 Aug 3

PMID 22854810

Citations 471

Authors

Peter Friedl

Joseph Locker

Erik Sahai

Jeffrey E Segall

Affiliations

Soon will be listed here.

Abstract

Most invasive solid tumours display predominantly collective invasion, in which groups of cells invade the peritumoral stroma while maintaining cell-cell contacts. As the concepts and experimental models for functional analysis of collective cancer cell invasion are rapidly developing, we propose a framework for addressing potential mechanisms, experimental strategies and technical challenges to study this process.

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