Overall Obesity, Abdominal Adiposity, Diabetes and Cigarette Smoking in Relation to the Risk of Pancreatic Cancer in Two Swedish Population-based Cohorts

Overview

Journal Br J Cancer

Specialty Oncology

Date 2005 Nov 17

PMID 16288300

Citations 66

Authors

S C Larsson

J Permert

N Hakansson

I Naslund

L Bergkvist

A Wolk

Affiliations

Soon will be listed here.

Abstract

We examined the associations of body mass index (BMI), waist circumference, a history of diabetes, and cigarette smoking with risk of pancreatic cancer among 37,147 women and 45,906 men followed up during 560,666 person-years in the Swedish Mammography Cohort and the Cohort of Swedish Men; 136 incident cases of pancreatic cancer were diagnosed. The multivariate rate ratio (RR) of pancreatic cancer for obese women and men (BMI > or =30 kg/m(2)) was 1.81 (95% CI: 1.04-3.15) compared to those with a BMI of 20-25 kg/m(2). For a difference of 20 cm (about two standard deviations) in waist circumference, the multivariate RRs were 1.32 (95% CI: 0.73-2.37) among women and 1.74 (95% CI: 1.00-3.01) among men. Pancreatic cancer risk was associated with history of diabetes (multivariate RR: 1.88; 95% CI: 1.09-3.26) and cigarette smoking (multivariate RR for current compared with never smokers: 3.06; 95% CI: 1.99-4.72). Current smokers of > or =40 pack-years had a five-fold elevated risk compared with never smokers. Risk among past smokers approached the RR for never smokers within 5-10 years following smoking cessation. Findings from this prospective study support positive relationships of overall obesity, abdominal adiposity, diabetes and smoking with risk of pancreatic cancer.

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References

Gapstur S, Gann P, Lowe W, Liu K, Colangelo L, Dyer A . Abnormal glucose metabolism and pancreatic cancer mortality. JAMA. 2000; 283(19):2552-8. DOI: 10.1001/jama.283.19.2552. View

Fryzek J, Schenk M, Kinnard M, Greenson J, Garabrant D . The association of body mass index and pancreatic cancer in residents of southeastern Michigan, 1996-1999. Am J Epidemiol. 2005; 162(3):222-8. DOI: 10.1093/aje/kwi183. View

Schneider M, Matsuzaki H, Haorah J, Ulrich A, Standop J, Ding X . Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology. 2001; 120(5):1263-70. DOI: 10.1053/gast.2001.23258. View

Berrington de Gonzalez A, Sweetland S, Spencer E . A meta-analysis of obesity and the risk of pancreatic cancer. Br J Cancer. 2003; 89(3):519-23. PMC: 2394383. DOI: 10.1038/sj.bjc.6601140. View

Sant M, Aareleid T, Berrino F, Bielska Lasota M, Carli P, Faivre J . EUROCARE-3: survival of cancer patients diagnosed 1990-94--results and commentary. Ann Oncol. 2003; 14 Suppl 5:v61-118. DOI: 10.1093/annonc/mdg754. View

Giovannucci E . Nutrition, insulin, insulin-like growth factors and cancer. Horm Metab Res. 2004; 35(11-12):694-704. DOI: 10.1055/s-2004-814147. View

Pan S, Johnson K, Ugnat A, Wen S, Mao Y . Association of obesity and cancer risk in Canada. Am J Epidemiol. 2004; 159(3):259-68. DOI: 10.1093/aje/kwh041. View

Samanic C, Gridley G, Chow W, Lubin J, Hoover R, Fraumeni Jr J . Obesity and cancer risk among white and black United States veterans. Cancer Causes Control. 2004; 15(1):35-43. DOI: 10.1023/B:CACO.0000016573.79453.ba. View

Spencer E, Roddam A, Key T . Accuracy of self-reported waist and hip measurements in 4492 EPIC-Oxford participants. Public Health Nutr. 2004; 7(6):723-7. DOI: 10.1079/phn2004600. View

10.

Henderson J, Daniel P, Fraser P . The pancreas as a single organ: the influence of the endocrine upon the exocrine part of the gland. Gut. 1981; 22(2):158-67. PMC: 1419227. DOI: 10.1136/gut.22.2.158. View

11.

Mattsson B, Wallgren A . Completeness of the Swedish Cancer Register. Non-notified cancer cases recorded on death certificates in 1978. Acta Radiol Oncol. 1984; 23(5):305-13. DOI: 10.3109/02841868409136026. View

12.

Williams J, Goldfine I . The insulin-pancreatic acinar axis. Diabetes. 1985; 34(10):980-6. DOI: 10.2337/diab.34.10.980. View

13.

Karlsson P, Stolt M, Rossner S . The predictive validity of body mass index based on self-reported weight and height. Int J Obes. 1989; 13(4):441-53. View

14.

Ohmura E, Okada M, Onoda N, Kamiya Y, Murakami H, Tsushima T . Insulin-like growth factor I and transforming growth factor alpha as autocrine growth factors in human pancreatic cancer cell growth. Cancer Res. 1990; 50(1):103-7. View

15.

Takeda Y, ESCRIBANO M . Effects of insulin and somatostatin on the growth and the colony formation of two human pancreatic cancer cell lines. J Cancer Res Clin Oncol. 1991; 117(5):416-20. DOI: 10.1007/BF01612760. View

16.

Silverman D, Dunn J, Hoover R, Schiffman M, Lillemoe K, Schoenberg J . Cigarette smoking and pancreas cancer: a case-control study based on direct interviews. J Natl Cancer Inst. 1994; 86(20):1510-6. DOI: 10.1093/jnci/86.20.1510. View

17.

Bergmann U, Funatomi H, Yokoyama M, Beger H, Korc M . Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res. 1995; 55(10):2007-11. View

18.

Fisher W, Boros L, Schirmer W . Insulin promotes pancreatic cancer: evidence for endocrine influence on exocrine pancreatic tumors. J Surg Res. 1996; 63(1):310-3. DOI: 10.1006/jsre.1996.0266. View

19.

Fuchs C, Colditz G, Stampfer M, Giovannucci E, Hunter D, Rimm E . A prospective study of cigarette smoking and the risk of pancreatic cancer. Arch Intern Med. 1996; 156(19):2255-60. View

20.

Le Roith D . Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med. 1997; 336(9):633-40. DOI: 10.1056/NEJM199702273360907. View