Consequential Late Effects After Radiotherapy for Prostate Cancer - a Prospective Longitudinal Quality of Life Study

Overview

Journal Radiat Oncol

Publisher Biomed Central

Specialties Oncology
Radiology

Date 2010 Apr 10

PMID 20377874

Citations 17

Authors

Michael Pinkawa

Richard Holy

Marc D Piroth

Karin Fischedick

Sandra Schaar

Dalma Szekely-Orban

Michael J Eble

Affiliations

Soon will be listed here.

Abstract

Background: To answer the question if and to which extent acute symptoms at the end and/or several weeks after radiotherapy can predict adverse urinary and gastrointestinal long-term quality of life (QoL).

Methods: A group of 298 patients has been surveyed prospectively before (time A), at the last day (B), two months after (C) and >one year after (D) radiotherapy using a validated questionnaire (Expanded Prostate Cancer Index Composite). A subgroup of 10% with the greatest urinary/bowel bother score decrease at time D was defined as patients with adverse long-term QoL.

Results: Subgroup and correlation analyses could demonstrate a strong dependence of urinary/bowel QoL after radiotherapy on urinary/bowel QoL before radiotherapy. In contrast to absolute scores, QoL score changes (relative to baseline scores) did not correlate with pretreatment scores. Long-term changes could be well predicted by acute changes. Patients reporting great/moderate bother with urinary/bowel problems at time C reported to have great/moderate bother at time D in > or = 50%, respectively. In a multivariate analysis of factors for adverse long-term urinary and bowel QoL, score changes at time C were found to be independent predictors, respectively. Additionally, QoL changes at time B were independently predictive for adverse long-term bowel QoL.

Conclusions: Consequential late effects play a major role after radiotherapy for prostate cancer. Patients with greater and particularly longer non-healing acute toxicity are candidates for closer follow-up and possible prophylactic actions to reduce a high probability of long-term problems.

Citing Articles

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Rationale for Utilization of Hydrogel Rectal Spacers in Dose Escalated SBRT for the Treatment of Unfavorable Risk Prostate Cancer.

Repka M, Creswell M, Lischalk J, Carrasquilla M, Forsthoefel M, Lee J Front Oncol. 2022; 12:860848.

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Linking CHHiP prostate cancer RCT with GP records: A study proposal to investigate the effect of co-morbidities and medications on long-term symptoms and radiotherapy-related toxicity.

Lemanska A, Byford R, Correa A, Cruickshank C, Dearnaley D, Griffin C Tech Innov Patient Support Radiat Oncol. 2020; 2:5-12.

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Intensity-modulated radiotherapy of prostate cancer with simultaneous integrated boost after molecular imaging with 18F-choline-PET/CT : Clinical results and quality of life.

Schlenter M, Berneking V, Krenkel B, Mottaghy F, Vogeli T, Eble M Strahlenther Onkol. 2018; 194(7):638-645.

PMID: 29511777 DOI: 10.1007/s00066-018-1282-6.

Older Age, Early Symptoms and Physical Function are Associated with the Severity of Late Symptom Clusters for Men Undergoing Radiotherapy for Prostate Cancer.

Lemanska A, Dearnaley D, Jena R, Sydes M, Faithfull S Clin Oncol (R Coll Radiol). 2018; 30(6):334-345.

PMID: 29459102 PMC: 5952898. DOI: 10.1016/j.clon.2018.01.016.

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