Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria

Overview

Journal Mol Interv

Specialty Molecular Biology

Date 2010 Apr 7

PMID 20368370

Citations 27

Authors

Dean P Jones

John J Lemasters

Derick Han

Urs A Boelsterli

Neil Kaplowitz

Affiliations

Soon will be listed here.

Abstract

Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal mitochondrial function impairs cellular energy and lipid metabolism and leads to the unleashing of mediators of cell death. The role of mitochondria in cell death due to drug hepatotoxicity has been receiving renewed attention and it is therefore timely to assess the current status of this area.

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